{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:02:40Z","timestamp":1791378160556,"version":"4.3.2"},"reference-count":24,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To evaluate the cardiopulmonary and sedative effects of the peripheral \u03b1<jats:sub>2<\/jats:sub>-adrenoceptor antagonist MK 0467 when administered IM or IV concurrently with medetomidine in dogs.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u20148 adult dogs.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Dogs received 20 \u03bcg of medetomidine\/kg, IM, alone or concurrently with MK 0467 (0.4 mg\/kg, IM), and 10 \u03bcg of medetomidine\/kg, IV, alone or concurrently with MK 0467 (0.2 mg\/kg, IV), in a randomized crossover study. Sedation characteristics were scored and hemodynamic measurements and arterial and mixed-venous blood samples for blood gas analysis were obtained before (time 0; baseline) and for 90 minutes after treatment.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Heart rate (HR), mixed-venous partial pressure of oxygen (P<jats:overline>v<\/jats:overline><jats:sc>o<\/jats:sc><jats:sub>2<\/jats:sub>), and cardiac index (CI) were significantly lower and mean arterial blood pressure (MAP), systemic vascular resistance (SVR), and oxygen extraction ratio (ER) were significantly higher after administration of medetomidine IM or IV, compared with baseline values. Administration of medetomidine and MK 0467 IM caused a significantly higher heart rate, CI, and P<jats:overline>v<\/jats:overline><jats:sc>o<\/jats:sc><jats:sub>2<\/jats:sub> and significantly lower MAP, SVR, and ER for 60 to 90 minutes than did IM administration of medetomidine alone. Administration of medetomidine and MK 0467 IV caused a significantly higher CI and P<jats:overline>v<\/jats:overline><jats:sc>o<\/jats:sc><jats:sub>2<\/jats:sub> and significantly lower MAP, SVR, and ER for 45 to 90 minutes than did IV administration of medetomidine alone. There was no significant difference in sedation scores among treatments.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014In dogs, MK 0467 administered concurrently with medetomidine IV or IM reduced the cardiovascular effects of medetomidine but had no detectable effect on sedation scores.<\/jats:p>","DOI":"10.2460\/ajvr.73.5.587","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T18:13:49Z","timestamp":1335377629000},"page":"587-594","source":"Crossref","is-referenced-by-count":52,"title":["Cardiopulmonary and sedative effects of the peripheral \u03b12-adrenoceptor antagonist MK 0467 administered intravenously or intramuscularly concurrently with medetomidine in dogs"],"prefix":"10.2460","volume":"73","author":[{"given":"Nicole G.","family":"Rolfe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn L.","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne N.","family":"McDonell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet Surg","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/j.1532-950X.1998.tb00539.x","article-title":"Hemodynamic effects of medetomidine in the dog: a dose titration study","volume":"27","author":"Pypendop","year":"1998"},{"key":"ref2","series-title":"Acta Vet Scand Suppl","first-page":"39","article-title":"Cardiovascular actions of medetomidine and their reversal by atipamezole","volume":"85","author":"Savola","year":"1989"},{"key":"ref3","series-title":"Acta Vet Scand","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1186\/BF03548016","article-title":"Cardiovascular and respiratory effects of medetomidine in dogs and influence of 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profiles of medetomidine and its antagonist, atipamezole","volume":"85","author":"Virtanen","year":"1989"},{"key":"ref24","series-title":"J Pharmacol Exp Ther","first-page":"32","article-title":"A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066","volume":"245","author":"Clineschmidt","year":"1988"}],"container-title":["American Journal of Veterinary 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