{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:56:23Z","timestamp":1791312983038,"version":"4.3.1"},"reference-count":35,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To evaluate the effect of acepromazine maleate administered IV on platelet function assessed in healthy dogs by use of a modified thromboelastography assay.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u20146 healthy adult mixed-breed dogs.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Dogs received each of 3 treatments (saline [0.9% NaCl] solution [1 to 2 mL, IV] and acepromazine maleate [0.05 and 0.1 mg\/kg, IV]) in a randomized crossover study with a minimum 3-day washout period between treatments. From each dog, blood samples were collected via jugular venipuncture immediately before and 30 and 240 minutes after administration of each treatment. A modified thromboelastography assay, consisting of citrated kaolin\u2013activated (baseline assessment), reptilase-ADP\u2013activated (ADP-activated), and reptilase-arachidonic acid (AA)\u2013activated (AA-activated) thromboelastography, was performed for each sample. Platelet inhibition was evaluated by assessing the percentage change in maximum amplitude for ADP-activated or AA-activated samples, compared with baseline values. Percentage change in maximum amplitude was analyzed by use of Skillings-Mack tests with significance accepted at a family-wise error rate of <jats:italic>P<\/jats:italic> &lt; 0.05 by use of Bonferroni corrections for multiple comparisons.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014No significant differences were found in the percentage change of maximum amplitude from baseline for ADP-activated or AA-activated samples among treatments at any time.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Platelet function in dogs, as assessed by use of a modified thromboelastography assay, was not inhibited by acepromazine at doses of 0.05 or 0.1 mg\/kg, IV. This was in contrast to previous reports in which it was suggested that acepromazine may alter platelet function via inhibition of ADP and AA.<\/jats:p>","DOI":"10.2460\/ajvr.73.5.595","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T18:13:49Z","timestamp":1335377629000},"page":"595-601","source":"Crossref","is-referenced-by-count":21,"title":["Effects of acepromazine maleate on platelet function assessed by use of adenosine diphosphate activated\u2013 and arachidonic acid\u2013 activated modified thromboelastography in healthy dogs"],"prefix":"10.2460","volume":"73","author":[{"given":"Bobbi J.","family":"Conner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita M.","family":"Hanel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard 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