{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T18:13:35Z","timestamp":1782497615258,"version":"3.54.5"},"reference-count":34,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine whether repeated oral administration of glucose and leucine during the period immediately after intense exercise would increase the release of insulin and thereby enhance glycogen synthesis in horses.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201412 Standardbred horses.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014In a crossover study design, after glycogen-depleting exercise, horses received oral boluses of glucose (1 g\/kg at 0, 2, and 4 hours) and leucine (0.1 g\/kg at 0 and 4 hours) or boluses of water (10 mL\/kg at 0, 2, and 4 hours; control treatment). Blood samples for determination of glucose, insulin, and leucine concentrations were collected prior to and during a 6-hour period immediately after exercise. Biopsy specimens of a gluteus muscle were obtained before and immediately after exercise and at 3, 6, and 24 hours after exercise for measurement of glycogen concentration.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014When glucose and leucine were administered to the horses, plasma insulin concentration was significantly higher during the 6 hours immediately after exercise than it was when water was administered to the horses. Serum glucose concentration during the 4 hours immediately after exercise was significantly higher when glucose and leucine were administered than the serum glucose concentration when water was administered. Muscle glycogen concentrations did not differ between the 2 treatments during the 24 hours after exercise.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Synthesis of muscle glycogen after intense intermittent exercise was not enhanced by oral boluses of glucose and leucine after exercise despite pronounced increases in plasma insulin and serum glucose concentrations.<\/jats:p>","DOI":"10.2460\/ajvr.73.6.867","type":"journal-article","created":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T20:02:35Z","timestamp":1337803355000},"page":"867-874","source":"Crossref","is-referenced-by-count":8,"title":["Effect of repeated oral administration of glucose and leucine immediately after exercise on plasma insulin concentration and glycogen synthesis in horses"],"prefix":"10.2460","volume":"73","author":[{"given":"Johan T.","family":"Br\u00f6jer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina E. 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