{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:29:44Z","timestamp":1782955784945,"version":"3.54.5"},"reference-count":38,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To evaluate and compare the gene expression of interleukin(IL)-1\u03b2, IL-8, and interferon-\u03b3 during the first 72 hours after birth in healthy foals and during the first 72 hours after hospitalization in sick neonatal foals and investigate correlations of clinicopathologic variables with cytokine expressions in healthy and sick neonatal foals.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201433 foals &lt; 7 days old (10 healthy foals, 7 foals with sepsis, 6 foals with peripartum asphyxia syndrome, and 12 foals with other diseases [2 with failure of passive transfer of immunity only were not further evaluated]).<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014A blood sample (15 mL) was collected from each foal immediately after birth or hospital admission (0 hours) and at 24 and 72 hours later. Clinicopathologic variables were evaluated, and cytokine gene expression in WBCs was measured with an absolute quantitative real-time reverse transcriptase PCR assay.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014At all time points, gene expression of interferon-\u03b3 was low in all groups. No time-dependent changes in cytokine expressions were detected in healthy or sick foals. Foals with sepsis had significantly higher IL-1\u03b2 gene expression than did healthy foals, foals with peripartum asphyxia syndrome, or foals with other diseases. At 0 hours, IL-1\u03b2 expression was correlated with plasma fibrinogen concentration in healthy foals and with the neutrophil-to-lymphocyte ratio in foals with sepsis; IL-8 expression was correlated with monocyte count in foals with sepsis and with arterial pH, plasma fibrinogen concentration, and plasma lactate concentration in foals with peripartum asphyxia syndrome.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Data have suggested that evaluation of IL-1\u03b2 expression in sick neonatal foals could help identify those with sepsis.<\/jats:p>","DOI":"10.2460\/ajvr.73.9.1418","type":"journal-article","created":{"date-parts":[[2012,8,27]],"date-time":"2012-08-27T15:35:31Z","timestamp":1346081731000},"page":"1418-1427","source":"Crossref","is-referenced-by-count":26,"title":["Expression of interleukin-1\u03b2, interleukin-8, and interferon-\u03b3 in blood samples obtained from healthy and sick neonatal 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