{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:28:40Z","timestamp":1778279320446,"version":"3.51.4"},"reference-count":29,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine the effects of carprofen and etodolac on renal function in euvolemic dogs and dogs with extracellular fluid volume depletion induced via administration of furosemide.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201412 female Beagles.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Dogs received a placebo, furosemide, carprofen, etodolac, furosemide and carprofen, and furosemide and etodolac. The order in which dogs received treatments was determined via a randomization procedure. Values of urine specific gravity, various plasma biochemical variables, glomerular filtration rate (GFR [urinary clearance of creatinine]), and renal plasma flow (urinary clearance of para-aminohippuric acid) were determined before and after 8 days of drug administration. A washout time of approximately 12 days was allowed between treatment periods.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Administration of furosemide, furosemide and carprofen, and furosemide and etodolac caused changes in urine specific gravity and values of plasma biochemical variables. Administration of carprofen or etodolac alone did not have a significant effect on renal plasma flow or GFR. Concurrent administration of furosemide and carprofen or furosemide and etodolac caused a significant decrease in GFR. After 12-day washout periods, mean values of GFR were similar to values before drug administration for all treatments.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results indicated GFR decreased after 8 days of concurrent administration of furosemide and carprofen or furosemide and etodolac to dogs. Administration of preferential cyclooxygenase-2 inhibitors to dogs with extracellular fluid volume depletion or to dogs treated with diuretics may transiently impair renal function.<\/jats:p>","DOI":"10.2460\/ajvr.73.9.1485","type":"journal-article","created":{"date-parts":[[2012,8,27]],"date-time":"2012-08-27T15:35:31Z","timestamp":1346081731000},"page":"1485-1490","source":"Crossref","is-referenced-by-count":17,"title":["Renal effects of carprofen and etodolac in euvolemic and volume-depleted dogs"],"prefix":"10.2460","volume":"73","author":[{"given":"Kathryn K.","family":"Surdyk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn L.","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Am Vet Med Assoc","first-page":"918","article-title":"Ibuprofen toxicosis in a dog","volume":"189","author":"Bacia","year":"1986"},{"key":"ref2","series-title":"Prev Vet Med","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0167-5877(98)00051-8","article-title":"A case-control study of acute ibuprofen toxicity in dogs","volume":"35","author":"Poortinga","year":"1998"},{"key":"ref3","series-title":"Toxicol Pathol","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1177\/019262338801600217","article-title":"The propionic acids. 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