{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:25:32Z","timestamp":1765545932716,"version":"3.38.0"},"reference-count":37,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To describe the anatomic and histologic features of the collateral ligaments (CLs) of the metacarpophalangeal (MCP) and metatarsophalangeal (MTP) joints in cadaveric limbs obtained from nonlame horses and to compare the histologic findings with the ultrasonographic appearance of the CLs.<\/jats:p>\n<jats:p><jats:bold>Sample<\/jats:bold>\u2014Medial and lateral CLs of the MCP and MTP joints of 28 limbs (16 forelimbs and 12 hind limbs) from 9 adult nonlame horses euthanized for reasons unrelated to the study.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u201426 limbs of 8 horses were examined by ultrasonography immediately after euthanasia. Postmortem gross and histologic examinations were performed for all 28 limbs. Histologic and ultrasonographic images were graded and compared.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Ultrasonographically, the mean \u00b1 SD depth and width of the superficial CL were 5.1 \u00b1 0.7 mm and 20.5 \u00b1 1.7 mm, respectively. On histologic examination, only 125 of 319 (39%) specimens obtained from 56 medial and lateral CLs appeared normal. Histopathologic findings varied from mild changes in cellular density and collagen fiber orientation to severe fibrocartilaginous metaplasia. The degree of CL lesion severity increased distally, and the lateral CL was affected more frequently than was the medial CL. Ultrasonographically detectable abnormalities were not correlated with the histologic findings.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014In horses, histologic abnormalities within the CLs of the MCP and MTP joints may be an adaptive response to joint hyperextension and compression and might predispose horses to desmopathy and ligament failure in the event of trauma. Ultrasonography did not detect morphologic changes of the CL matrix. For an accurate diagnosis of subclinical lesions, more sensitive imaging techniques (eg, MRI) should be considered.<\/jats:p>","DOI":"10.2460\/ajvr.75.12.1089","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T19:41:02Z","timestamp":1416858062000},"page":"1089-1098","source":"Crossref","is-referenced-by-count":5,"title":["Anatomic and histologic features and ultrasonographic appearance of the collateral ligaments of the metacarpophalangeal and metatarsophalangeal joints in cadaveric limbs from horses without lameness"],"prefix":"10.2460","volume":"75","author":[{"given":"Friederike","family":"Pohlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Edinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florien","family":"Jenner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Egerbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"26","DOI":"10.2746\/042516401776767377","article-title":"Contact areas and pressure distribution on the proximal articular surface of the proximal phalanx under sagittal plane loading","volume":"33","author":"Brama","year":"2001"},{"key":"ref2","series-title":"Diagnosis and management of lameness in the horse","first-page":"394","article-title":"The metacarpophalangeal joint","author":"Richardson","year":"2011"},{"key":"ref3","series-title":"Anatomy of the horse","first-page":"114","article-title":"Contributions to clinical-functional anatomy: thoracic limb","author":"Patan","year":"2009"},{"key":"ref4","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"456","DOI":"10.2460\/javma.233.3.456","article-title":"Rupture of collateral ligaments in metacarpophalangeal and metatarsophalangeal joints in horses: 17 cases (1999\u20132005)","volume":"233","author":"Tenney","year":"2008"},{"key":"ref5","series-title":"Equine diagnostic ultrasound","first-page":"47","article-title":"Musculoskeletal ultrasonography","author":"Reef","year":"1998"},{"key":"ref6","series-title":"Vet Clin North Am Equine Pract","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0749-0739(17)30322-X","article-title":"Ligaments associated with joints","volume":"11","author":"Wright","year":"1995"},{"key":"ref7","series-title":"Vet Radiol Ultrasound","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/j.1740-8261.2012.01983.x","article-title":"MRI findings in 232 horses with lameness localized to the metacarpo(tarso)phalangeal region and without a radiographic diagnosis","volume":"54","author":"King","year":"2013"},{"key":"ref8","series-title":"Vet Radiol Ultrasound","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/j.1740-8261.2010.01676.x","article-title":"MRI features of metacarpo(tarso)phalangeal region lameness in 40 horses","volume":"51","author":"Gonzalez","year":"2010"},{"key":"ref9","series-title":"Pferdeheilkunde","first-page":"353","article-title":"Die Aussagekraft der sonographischen Untersuchung von Gelenken","volume":"26","author":"Edinger","year":"2010"},{"key":"ref10","series-title":"Vlaams Diergeneeskundig Tijdschr","first-page":"263","article-title":"Anatomy and imaging of the equine metacarpophalangeal\/metatarsophalangeal joint","volume":"80","author":"Hauspie","year":"2011"},{"key":"ref11","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/j.2042-3306.1996.tb01590.x","article-title":"Ultrasonographic anatomy of the dorsal and abaxial aspects of the equine fetlock","volume":"28","author":"Denoix","year":"1996"},{"key":"ref12","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"508","DOI":"10.2746\/042516406X156109","article-title":"Magnetic resonance imaging, ultrasonography and histology of the suspensory ligament origin: a comparative study of normal anatomy of Warmblood horses","volume":"38","author":"Bischofberger","year":"2006"},{"key":"ref13","series-title":"Equine diagnostic ultrasonography","first-page":"475","article-title":"Joints and miscellaneous tendons (miscellaneous tendons and ligaments)","author":"Denoix","year":"1998"},{"key":"ref14","series-title":"Clin Tech Equine Pract","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1053\/j.ctep.2005.02.003","article-title":"Joint ultrasonography","volume":"3","author":"Reef","year":"2004"},{"key":"ref15","series-title":"Bull Acad Vet Fr","first-page":"313","article-title":"Ultrasonographic examination of joints, a revolution in equine locomotor pathology","volume":"162","author":"Denoix","year":"2009"},{"key":"ref16","series-title":"Vet Clin North Am Equine Pract","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0749-0739(17)30738-1","article-title":"Diagnostic ultrasonography of equine limbs","volume":"2","author":"Genovese","year":"1986"},{"key":"ref17","series-title":"Dubai Intern Equine Symp","first-page":"423","article-title":"Treatment of superficial digital flexor tendon injuries with beta-aminopropionitrile fumarate (BAPN-F): sonographic evaluation of early tendon healing and remodeling","author":"Reef","year":"1996"},{"key":"ref18","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"538","DOI":"10.2746\/042516408X313661","article-title":"The collateral ligaments of the distal interphalangeal joint: magnetic resonance imaging and post mortem observations in 25 lame and 12 control horses","volume":"40","author":"Dyson","year":"2008"},{"key":"ref19","series-title":"Reg Anesth Pain Med","first-page":"419","article-title":"Artifacts and pitfall errors associated with ultrasound-guided regional anesthesia. Part II: a pictorial approach to understanding and avoidance","volume":"32","author":"Sites","year":"2007"},{"key":"ref20","series-title":"Praxisorientierte Anatomie und Prop\u00e4deutik des Pferdes","first-page":"422","article-title":"Die Schultergliedma\u00dfe. Fesselgelenk","author":"Wissdorf","year":"2010"},{"key":"ref21","series-title":"Anatomie compar\u00e9e des mammif\u00e8res domestiques. Tome 2, Arthrologie et Myologie","first-page":"189","article-title":"Articulations m\u00e9tacarpo-phalangiennes","author":"Barone","year":"2000"},{"key":"ref22","series-title":"Textbook of veterinary anatomy","first-page":"568","article-title":"The forelimb of the horse","author":"Dyce","year":"2010"},{"key":"ref23","series-title":"Adams & Stashak's lameness in horses","first-page":"1","article-title":"Functional anatomy of the equine musculoskeletal system","author":"Kainer","year":"2011"},{"key":"ref24","series-title":"Clin Tech Equine Pract","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1053\/j.ctep.2007.08.008","article-title":"Magnetic resonance imaging of tendon and ligament injuries","volume":"6","author":"Zubrod","year":"2007"},{"key":"ref25","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"631","DOI":"10.2460\/ajvr.69.5.631","article-title":"Evaluation of computer tomographic anatomy of the equine metacarpophalangeal joint","volume":"69","author":"Vanderperren","year":"2008"},{"key":"ref26","series-title":"Scand J Med Sci Sports","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1034\/j.1600-0838.2000.010006312.x","article-title":"Structure of the tendon connective tissue","volume":"10","author":"Kannus","year":"2000"},{"key":"ref27","series-title":"Clin Tech Equine Pract","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1053\/j.ctep.2007.08.002","article-title":"Pathobiology of tendon and ligament injuries","volume":"6","author":"Dahlgren","year":"2007"},{"key":"ref28","series-title":"J Orthop Res","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/jor.20218","article-title":"Tendons and ligaments are anatomically distinct but overlap in molecular and morphological features\u2014a comparative study in an ovine model","volume":"25","author":"Rumian","year":"2007"},{"key":"ref29","series-title":"Equine sports medicine and surgery: basic and clinical sciences of the equine athlete","first-page":"130","article-title":"Tendon and ligament physiology","author":"Smith","year":"2004"},{"key":"ref30","series-title":"J Biomech","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jbiomech.2004.10.025","article-title":"Biomechanics of knee ligaments: injury, healing and repair","volume":"39","author":"Woo","year":"2006"},{"key":"ref31","series-title":"Int J Exp Pathol","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1365-2613.2007.00548.x","article-title":"The mechanobiological aethiopathogenesis of tendinopathy: is it the over-stimulation or the under-stimulation of tendon cells?","volume":"88","author":"Arnoczky","year":"2007"},{"key":"ref32","series-title":"Equine Vet J Suppl","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/j.2042-3306.2001.tb05366.x","article-title":"Normal three-dimensional behaviour of the metacarpophalangeal joint and the effect of uneven foot bearing","volume":"33","author":"Chateau","year":"2001"},{"key":"ref33","series-title":"J Biomech","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1016\/j.jbiomech.2005.08.008","article-title":"Isolated fibrillar damage in tendons stimulates local collagenase mRNA expression and protein synthesis","volume":"39","author":"Lavagnino","year":"2006"},{"key":"ref34","series-title":"J Anat","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1046\/j.1469-7580.1998.19340481.x","article-title":"Fibrocartilage in tendons and ligaments\u2014an adaption to compressive load","volume":"193","author":"Benjamin","year":"1998"},{"key":"ref35","series-title":"J Shoulder Elbow Surg","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.jse.2003.12.015","article-title":"Fibrous cartilage in the rotator cuff: a pathogenetic mechanism of tendon tear?","volume":"13","author":"Gigante","year":"2004"},{"key":"ref36","series-title":"Int Rev Cytol","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0074-7696(00)96003-0","article-title":"The cell and developmental biology of tendons and ligaments","volume":"196","author":"Benjamin","year":"2000"},{"key":"ref37","series-title":"J Orthop Res","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/jor.1100050109","article-title":"Biochemical, histological, and biomechanical analyses of canine tendon","volume":"5","author":"Okuda","year":"1987"}],"container-title":["American Journal of Veterinary 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