{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:15:45Z","timestamp":1778055345507,"version":"3.51.4"},"reference-count":47,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine associations of blood analysis variables and orbit and nasal planum surface temperatures with the onset and severity of <jats:italic>Mycoplasma bovis<\/jats:italic> pneumonia in calves.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201428 healthy calves.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Calves were challenged with <jats:italic>M bovis<\/jats:italic> (n = 24) on day 0 or not challenged (4). Blood samples were obtained for cardiac troponin I, CBC, and serum biochemical analyses on various days. Orbit and nasal planum surface temperatures were determined with infrared thermography on various days. Calves were euthanized, gross necropsies were performed, heart and lung samples were collected for histologic evaluation, and microbial cultures of lung samples were performed on day 14. Pneumonia severity was categorized as mild (&lt; 10% lung consolidation) or moderate (\u2265 10% lung consolidation). Associations between measured variables and severity of pneumonia or sample collection day were determined.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Plasma cardiac troponin I concentration for the 28 calves was significantly higher on day 14 than it was on day 0 or 7 (least squares mean, 0.02, 0, and 0 ng\/mL, respectively). No other variables changed significantly during the study. No substantial gross or histologic abnormalities were identified in cardiac muscle samples. Day 14 plasma fibrinogen concentration was significantly different between calves with mild pneumonia and those with moderate pneumonia (mean, 0.44 and 0.74 g\/dL, respectively). Calves with moderate pneumonia had significantly lower least squares mean surface temperature of the dorsal aspect of the nasal planum (18.7\u00b0C) versus calves with mild pneumonia (22.9\u00b0C).<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results indicated the evaluated variables had low value for assessment of bovine respiratory disease complex in calves.<\/jats:p>","DOI":"10.2460\/ajvr.75.2.200","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T17:52:20Z","timestamp":1390931540000},"page":"200-207","source":"Crossref","is-referenced-by-count":16,"title":["Associations of various physical and blood analysis variables with experimentally induced Mycoplasma bovis pneumonia in calves"],"prefix":"10.2460","volume":"75","author":[{"given":"Brandon C.","family":"Fraser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad J.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt D.","family":"Miesner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Lakritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Amrine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek A.","family":"Mosier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet Clin North Am Food Anim Pract","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S0749-0720(15)30302-9","article-title":"Economic impact associated with respiratory disease in beef cattle","volume":"13","author":"Griffin","year":"1997"},{"key":"ref2","series-title":"Vet Clin North Am Food Anim Pract","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cvfa.2006.03.009","article-title":"Bovine respiratory disease: pathogenesis, clinical signs, and treatment in lightweight calves","volume":"22","author":"Apley","year":"2006"},{"key":"ref3","series-title":"Can J Vet Res","first-page":"281","article-title":"Serological titers to bovine herpesvirus 1, bovine viral diarrhea virus, parainfluenza 3 virus, bovine respiratory syncytial virus and Pasteurella haemolytica in feedlot calves with respiratory disease: associations with bacteriological and pulmonary cytological variables","volume":"56","author":"Allen","year":"1992"},{"key":"ref4","series-title":"Anim Health Res Rev","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1017\/S1466252309990193","article-title":"Update on bacterial pathogenesis in BRD","volume":"10","author":"Confer","year":"2009"},{"key":"ref5","series-title":"Vet Clin North Am Food Anim Pract","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cvfa.2008.10.007","article-title":"Respiratory disease of the bovine neonate","volume":"25","author":"Poulsen","year":"2009"},{"key":"ref6","series-title":"Comp Immunol Microbiol Infect Dis","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cimid.2010.02.001","article-title":"The effect of various Mycoplasma bovis isolates on bovine leukocyte responses","volume":"34","author":"Wiggins","year":"2011"},{"key":"ref7","series-title":"Vet Clin North Am Food Anim Pract","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.cvfa.2008.10.011","article-title":"Mycoplasma bovis infections in young calves","volume":"25","author":"Maunsell","year":"2009"},{"key":"ref8","series-title":"Vet Clin North Am Food Anim Pract","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.cvfa.2010.03.003","article-title":"Mycoplasma bovis in respiratory disease of feedlot cattle","volume":"26","author":"Caswell","year":"2010"},{"key":"ref9","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1136\/vr.c5965","article-title":"et al. 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