{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:55:29Z","timestamp":1779400529186,"version":"3.53.1"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To characterize the relationship between plasma dexmedetomidine concentration and the temperature difference between the thermal threshold and skin temperature (\u0394T) and between plasma dexmedetomidine concentration and sedation score in healthy cats.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u20145 healthy adult spayed female cats.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Cats received IV administrations of saline (0.9% NaCl) solution, dexmedetomidine (5, 20, or 50 \u03bcg\/kg), or acepromazine (0.1 mg\/kg). Blood samples were collected and thermal threshold and sedation score were determined before and at various times up to 8 hours after drug administration. In addition, cats received an IV infusion of dexmedetomidine that targeted a concentration achieving 99% of the maximum effect on \u0394T.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014No change in \u0394T over time was found for the saline solution and acepromazine treatments; \u0394T increased for 45 minutes when cats received dexmedetomidine at 5 and 20 \u03bcg\/kg and for 180 minutes when cats received dexmedetomidine at 50 \u03bcg\/kg. No change in sedation score over time was found for saline solution. Sedation score increased for 120 minutes after cats received acepromazine and for 60, 120, and 180 minutes after cats received dexmedetomidine at 5, 20, and 50 \u03bcg\/kg, respectively. The plasma dexmedetomidine concentration\u2013effect relationships for the effect on \u0394T and sedation score were almost identical. The plasma dexmedetomidine concentration after infusion was lower than targeted, and \u0394T was not significantly affected.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Dexmedetomidine administration to cats resulted in thermal analgesia and also profound sedation. These data may be useful for predicting the course of thermal analgesia and sedation after dexmedetomidine administration to cats.<\/jats:p>","DOI":"10.2460\/ajvr.75.5.446","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T17:59:31Z","timestamp":1398362371000},"page":"446-452","source":"Crossref","is-referenced-by-count":23,"title":["Relationship between plasma dexmedetomidine concentration and sedation score and thermal threshold in cats"],"prefix":"10.2460","volume":"75","author":[{"given":"Bruno H.","family":"Pypendop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan E.","family":"Ilkiw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Vet Pharmacol Ther","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/j.1365-2885.2007.00931.x","article-title":"Thermal antinociception after 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