{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:56:57Z","timestamp":1788875817516,"version":"build-2803163510"},"reference-count":58,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To compare the effects of 2 NSAIDs (phenylbutazone and meloxicam) on renal function in horses.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u20149 Thoroughbred or Standardbred mares (mean \u00b1 SD age, 5.22 \u00b1 1.09 years [range, 2 to 12 years]; mean body weight, 470 \u00b1 25 kg [range, 442 to 510 kg]).<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014A randomized blinded placebo-controlled crossover study was conducted to examine the effects of treatment with phenylbutazone, meloxicam, or a placebo (control solution) on renal responses to the administration of furosemide, dobutamine, and exercise (15 minutes at 60% of maximum heart rate). Renal function was assessed by use of bilateral ureteral catheterization for simultaneous determination of creatinine clearance, sodium excretion, and urine flow rate.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Both phenylbutazone and meloxicam attenuated diuresis and natriuresis and reduced glomerular filtration rate, compared with results for the control solution, when horses were treated with furosemide. Mean arterial blood pressure, urine flow rate, and glomerular filtration rate were increased during or after (or both) dobutamine infusion. Both NSAIDs reduced urine flow rate and sodium excretion associated with dobutamine infusion and exercise but had no effect on glomerular filtration rate.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Responses to meloxicam, a cyclooxygenase (COX)-2 preferential agent, appeared comparable to those detected after phenylbutazone treatment, which suggested that COX-2 was the mediator of prostanoid-induced changes to renal function in horses and indicated that COX-2\u2013preferential agents would be likely to have adverse renal effects similar to those for nonselective COX inhibitors in volume-depleted horses.<\/jats:p>","DOI":"10.2460\/ajvr.75.7.668","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T13:45:32Z","timestamp":1403617532000},"page":"668-679","source":"Crossref","is-referenced-by-count":17,"title":["Effects of meloxicam and phenylbutazone on renal responses to furosemide, dobutamine, and exercise in horses"],"prefix":"10.2460","volume":"75","author":[{"given":"Sharanne L.","family":"Raidal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris J.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda-Lee","family":"Charman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon G.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline K.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenys K.","family":"Noble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Biol 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