{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:12:05Z","timestamp":1772691125511,"version":"3.50.1"},"reference-count":22,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To compare the attenuation of the angiotensin I\u2013induced blood pressure response by once-daily oral administration of various doses of angiotensin receptor blockers (irbesartan, telmisartan, and losartan), benazepril hydrochloride, or lactose monohydrate (placebo) for 8 days in clinically normal cats.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 6 healthy cats (approx 17 months old) with surgically implanted arterial telemetric blood pressure\u2013measuring catheters.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> Cats were administered orally the placebo or each of the drug treatments (benazepril [2.5 mg\/cat], irbesartan [6 and 10 mg\/kg], telmisartan [0.5, 1, and 3 mg\/kg], and losartan [2.5 mg\/kg]) once daily for 8 days in a crossover study. Approximately 90 minutes after capsule administration on day 8, each cat was anesthetized and arterial blood pressure measurements were recorded before and after IV administration of each of 4 boluses of angiotensin I (20, 100, 500, and 1,000 ng\/kg). This protocol was repeated 24 hours after benazepril treatment and telmisartan (3 mg\/kg) treatment. Differences in the angiotensin I\u2013induced change in systolic arterial blood pressure (\u0394SBP) among treatments were determined.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> At 90 minutes after capsule administration, only losartan did not significantly reduce \u0394SBP in response to the 3 higher angiotensin doses, compared with placebo. Among drug treatments, telmisartan (3 mg\/kg dosage) attenuated \u0394SBP to a significantly greater degree than benazepril and all other treatments. At 24 hours, telmisartan was more effective than benazepril (mean \u00b1 SEM \u0394SBP, 15.7 \u00b1 1.9 mm Hg vs 55.9 \u00b1 12.42 mm Hg, respectively).<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> Results indicated that telmisartan administration may have advantages over benazepril administration for cats with renal or cardiovascular disease.<\/jats:p>","DOI":"10.2460\/ajvr.76.9.807","type":"journal-article","created":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T15:36:56Z","timestamp":1440603416000},"page":"807-813","source":"Crossref","is-referenced-by-count":28,"title":["Attenuation of the pressor response to exogenous angiotensin by angiotensin receptor blockers and benazepril hydrochloride in clinically normal cats"],"prefix":"10.2460","volume":"76","author":[{"given":"Tiffany L.","family":"Jenkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda E.","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad W.","family":"Schmiedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.2460\/javma.2002.220.1799","article-title":"Prevalence of systolic hypertension in cats with chronic renal failure at initial evaluation","volume":"220","author":"Syme","year":"2002"},{"key":"ref2","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1939-1676.1990.tb03104.x","article-title":"Hypertension in cats with chronic renal failure or hyperthyroidism","volume":"4","author":"Kobayashi","year":"1990"},{"key":"ref3","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1111\/j.1939-1676.2006.tb02892.x","article-title":"Survival of cats with naturally occurring chronic renal failure is related to severity of proteinuria","volume":"20","author":"Syme","year":"2006"},{"key":"ref4","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.1939-1676.2011.00874.x","article-title":"Clinicopathological variables predicting progression of azotemia in cats with chronic kidney disease","volume":"26","author":"Chakrabarti","year":"2012"},{"key":"ref5","series-title":"Am J Vet Res","first-page":"535","article-title":"Plasma renin activity and angiotensin I and aldosterone concentrations in cats with hypertension associated with chronic renal disease","volume":"58","author":"Jensen","year":"1997"},{"key":"ref6","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.2460\/ajvr.2004.65.1006","article-title":"Evaluation of a technique of inducing hypertensive renal insufficiency in cats","volume":"65","author":"Mathur","year":"2004"},{"key":"ref7","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"375","DOI":"10.2460\/ajvr.2001.62.375","article-title":"Effects of the angiotensin converting enzyme inhibitor benazepril in cats with induced renal insufficiency","volume":"62","author":"Brown","year":"2001"},{"key":"ref8","series-title":"Ann Intern Med","doi-asserted-by":"publisher","first-page":"337","DOI":"10.7326\/0003-4819-127-5-199709010-00001","article-title":"Effect of angiotensin-converting enzyme inhibitors on the progression of nondiabetic renal disease: a meta-analysis of randomized trials. 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