{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:51:33Z","timestamp":1772765493526,"version":"3.50.1"},"reference-count":37,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To determine the efficacy of <jats:italic>Bdellovibrio bacteriovorus<\/jats:italic> 109J for the treatment of calves with experimentally induced infectious bovine keratoconjunctivitis (IBK).<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 12 healthy dairy calves.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> For each calf, a grid keratotomy was performed on both eyes immediately before inoculation with <jats:italic>Moraxella bovis<\/jats:italic> hemolytic strain Epp63\u2013300 (n = 11 calves) or nonhemolytic strain 12040577 (1 calf). For each calf inoculated with <jats:italic>M bovis<\/jats:italic> Epp63\u2013300, the eyes were randomly assigned to receive an artificial tear solution with (treatment group) or without (control group) lyophilized <jats:italic>B bacteriovorus<\/jats:italic> 109J. Six doses of the assigned treatment (0.2 mL\/eye, topically, q 48 h) were administered to each eye. On nontreatment days, eyes were assessed and corneal swab specimens and tear samples were collected for bacterial culture. Calves were euthanized 12 days after <jats:italic>M bovis<\/jats:italic> inoculation. The eyes were harvested for gross and histologic evaluation and bacterial culture.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> The calf inoculated with <jats:italic>M bovis<\/jats:italic> 12040577 did not develop corneal ulcers. Of the 22 eyes inoculated with <jats:italic>M bovis<\/jats:italic> Epp63\u2013300, 18 developed corneal ulcers consistent with IBK within 48 hours after inoculation; 4 of those eyes developed secondary corneal ulcers that were not consistent with IBK. Corneal ulcer size and severity and the time required for ulcer healing did not differ between the treatment and control groups.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> Results suggested that <jats:italic>B bacteriovorus<\/jats:italic> 109J was not effective for the treatment of IBK; however, the experimental model used produced lesions that did not completely mimic naturally occurring IBK.<\/jats:p>","DOI":"10.2460\/ajvr.77.9.1017","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T18:39:39Z","timestamp":1472668779000},"page":"1017-1028","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy of Bdellovibrio bacteriovorus 109J for the treatment of dairy calves with experimentally induced infectious bovine keratoconjunctivitis"],"prefix":"10.2460","volume":"77","author":[{"given":"M\u00e9lanie 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