{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:04:52Z","timestamp":1787742292486,"version":"build-2784847793"},"reference-count":49,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To evaluate the correlation between the density of native gastric <jats:italic>Helicobacter<\/jats:italic> spp and the presence of gastric lesions in dogs.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 80 dogs of various breeds, sexes, and ages.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> Gastroscopic and histologic examinations were performed for all dogs. <jats:italic>Helicobacter<\/jats:italic> spp were detected by combining evaluation of urease activity and results of bacteriologic culture, microscopic observation, and a 16S rRNA PCR assay. The density of <jats:italic>Helicobacter<\/jats:italic>-like organisms was evaluated with light microscopy by use of Warthin-Starry modified stain. Correlations were evaluated by use of the Spearman correlation analysis.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> Gastritis was found in 55 of 80 dogs and classified as mild (n = 31), moderate (16), or severe (8). Of these 55 dogs, only 8 had clinical signs. Histologic examination revealed some degree of lymphocytic-plasmacytic infiltrate, mild eosinophilia, and neutrophilic inflammation in the lamina propria. Seventy-six dogs had positive results for <jats:italic>Helicobacter<\/jats:italic> spp. <jats:italic>Helicobacter pylori<\/jats:italic> DNA was not detected. Low density and homogeneous distribution of <jats:italic>Helicobacter<\/jats:italic> spp were observed in all gastric zones.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> A significant correlation between density of <jats:italic>Helicobacter<\/jats:italic> spp and gastroscopic or histologic lesions was not detected. These findings supported the contention that there is no correlation between general <jats:italic>Helicobacter<\/jats:italic> spp density or numbers and gastritis in dogs.<\/jats:p>","DOI":"10.2460\/ajvr.78.12.1414","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T14:29:50Z","timestamp":1511879390000},"page":"1414-1420","source":"Crossref","is-referenced-by-count":10,"title":["Analysis of the association between density of Helicobacter spp and gastric lesions in 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