{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:45:43Z","timestamp":1773362743570,"version":"3.50.1"},"reference-count":31,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To examine bile acid composition of gallbladder contents in dogs with gallbladder mucocele and biliary sludge.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 18 dogs with gallbladder mucocele (GBM group), 8 dogs with immobile biliary sludge (i-BS group), 17 dogs with mobile biliary sludge (m-BS group), and 14 healthy dogs (control group).<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> Samples of gallbladder contents were obtained by use of percutaneous ultrasound-guided cholecystocentesis or during cholecystectomy or necropsy. Concentrations of 15 bile acids were determined by use of highperformance liquid chromatography, and a bile acid compositional ratio was calculated for each group.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> Concentrations of most bile acids in the GBM group were significantly lower than those in the control and m-BS groups. Compositional ratio of taurodeoxycholic acid, which is 1 of 3 major bile acids in dogs, was significantly lower in the GBM and i-BS groups, compared with ratios for the control and m-BS groups. The compositional ratio of taurocholic acid was significantly higher and that of taurochenodeoxycholic acid significantly lower in the i-BS group than in the control group.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> In this study, concentrations and fractions of bile acids in gallbladder contents were significantly different in dogs with gallbladder mucocele or immobile biliary sludge, compared with results for healthy control dogs. Studies are needed to determine whether changes in bile acid composition are primary or secondary events of gallbladder abnormalities.<\/jats:p>","DOI":"10.2460\/ajvr.78.2.223","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T17:18:38Z","timestamp":1485883118000},"page":"223-229","source":"Crossref","is-referenced-by-count":14,"title":["Bile acid composition of gallbladder contents in dogs with gallbladder mucocele and biliary 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