{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:20:11Z","timestamp":1790040011652,"version":"4.0.1"},"reference-count":35,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To measure serum homocysteine concentrations in dogs with myxomatous mitral valve disease (MMVD) and identify any association between this variable and stage of MMVD.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 53 client-owned dogs with MMVD and 10 healthy control Beagles.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> Dogs with MMVD were allocated to 3 groups in accordance with the staging system for chronic valvular heart disease in dogs and cats of the American College of Veterinary Internal Medicine. Blood samples were collected from all dogs, and serum homocysteine and cardiac troponin 1 concentrations were measured by enzyme immunoassay and chemiluminescence immunoassay, respectively. Analyte values were tested for associations with each other and with stage of MMVD.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> A significant correlation was identified between serum homocysteine concentration and stage of MMVD. Mean \u00b1 SD concentrations were 6.72 \u00b1 1.65 \u03bcmol\/L for control dogs, 13.37 \u00b1 4.16 \u03bcmol\/L for dogs with stage B MMVD, 18.86 \u00b1 6.73 \u03bcmol\/L for dogs with stage C disease, and 28.26 \u00b1 4.48 \u03bcmol\/L for dogs with stage D disease. In addition, serum homocysteine concentration was correlated with serum cardiac troponin 1 (<jats:italic>r<\/jats:italic> = 0.34) and creatinine (<jats:italic>r<\/jats:italic> = 0.46) concentrations, systolic blood pressure (<jats:italic>r<\/jats:italic> = 0.57), and left atrium-to-aortic root ratio (<jats:italic>r<\/jats:italic> = 0.28), all of which were positively correlated with stage of MMVD.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> Serum homocysteine concentrations of dogs with MMVD were significantly higher than those of control dogs, and significant correlations were identified between these values and several risk factors for heart failure. Measurement of serum homocysteine concentration may be useful in the prediction of severity of disease in dogs with MMVD.<\/jats:p>","DOI":"10.2460\/ajvr.78.4.440","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T19:29:47Z","timestamp":1490642987000},"page":"440-446","source":"Crossref","is-referenced-by-count":11,"title":["Correlation between serum homocysteine concentration and severity of mitral valve disease in dogs"],"prefix":"10.2460","volume":"78","author":[{"given":"Chang-Min","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Min","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Hee","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Gon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Ik","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Myung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Am Soc Nephrol","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1681\/ASN.V12102181","article-title":"The kidney and homocysteine metabolism","volume":"12","author":"Friedman","year":"2001"},{"key":"ref2","series-title":"Clin Chem","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1373\/clinchem.2003.021634","article-title":"Facts and recommendations about total homocysteine determinations: an expert opinion","volume":"50","author":"Refsum","year":"2004"},{"key":"ref3","series-title":"Annu Rev Med","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1146\/annurev.med.49.1.31","article-title":"Homocysteine and cardiovascular disease","volume":"49","author":"Refsum","year":"1998"},{"key":"ref4","series-title":"Blood","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.1182\/blood.V79.11.2930.2930","article-title":"An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin expression in human umbilical vein endothelial cells","volume":"79","author":"Hayashi","year":"1992"},{"key":"ref5","series-title":"Cardiol J","first-page":"55","article-title":"Plasma homocysteine and the severity of heart failure in patients with previous myocardial infarction","volume":"18","author":"Agoston-Coldea","year":"2011"},{"key":"ref6","series-title":"J Am Coll Cardiol","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.jacc.2011.05.028","article-title":"Homocysteine and reclassification of cardiovascular disease risk","volume":"58","author":"Veeranna","year":"2011"},{"key":"ref7","series-title":"J Thromb Thrombolysis","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s11239-011-0550-4","article-title":"Hyper-homocysteinemia: a novel risk factor or a powerful marker for cardiovascular diseases? 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