{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:15:32Z","timestamp":1773134132936,"version":"3.50.1"},"reference-count":69,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To determine the plasma total antioxidant capacity, erythrocyte superoxide dismutase activity, whole blood glutathione peroxidase activity, and plasma coenzyme Q<jats:sub>10<\/jats:sub> (CoQ<jats:sub>10<\/jats:sub>) concentration in dogs with various stages of cardiovascular diseases and in healthy dogs; assess the influence of cardiac treatment on the levels of antioxidant variables, plasma CoQ<jats:sub>10<\/jats:sub> concentration, and serum N-terminal pro-brain natriuretic peptide (NT-proBNP) concentration, and determine any correlation between the disease severity (NT-proBNP concentration) and antioxidant variables or CoQ<jats:sub>10<\/jats:sub> concentration.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 43 dogs with various types and stages of cardiovascular diseases (congenital and acquired) and 29 healthy dogs.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> Blood samples were collected from all dogs for spectrophotometric assessment of antioxidant variables. Plasma CoQ<jats:sub>10<\/jats:sub> concentration was determined with a high-performance liquid chromatography\u2013atmospheric pressure chemical ionization\u2013tandem mass spectrometry method. Serum NT-proBNP concentration was measured with an ELISA.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> Values for antioxidant variables did not differ among groups of dogs with cardiovascular diseases, regardless of disease stage or treatment. Plasma CoQ<jats:sub>10<\/jats:sub> concentration was significantly increased in treated dogs with congestive heart failure (CHF), compared with untreated patients. However, plasma CoQ<jats:sub>10<\/jats:sub> concentration did not differ among heart failure classes. A significant, negative correlation between serum NT-proBNP and plasma CoQ<jats:sub>10<\/jats:sub> concentrations was identified in treated CHF-affected dogs, suggesting that low plasma CoQ<jats:sub>10<\/jats:sub> concentration may be associated with increased severity of CHF.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> The antioxidant variables evaluated were not altered in dogs with CHF, regardless of cardiac disease stage or treatment. Further investigation into the possible effects of CoQ<jats:sub>10<\/jats:sub> supplementation in dogs with advanced stages of CHF is warranted.<\/jats:p>","DOI":"10.2460\/ajvr.78.4.447","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T19:29:47Z","timestamp":1490642987000},"page":"447-457","source":"Crossref","is-referenced-by-count":11,"title":["Plasma coenzyme Q10 concentration, antioxidant status, and serum N-terminal pro-brain natriuretic peptide concentration in dogs with various cardiovascular diseases and the effect of cardiac treatment on measured variables"],"prefix":"10.2460","volume":"78","author":[{"given":"Alenka Nemec","family":"Svete","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Verk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alenka","family":"Seli\u0161kar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Tomsi\u010d","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra Jazbec","family":"Kri\u017eman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra Domanjko","family":"Petri\u010d","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Physiol Rev","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Dr\u00f6ge","year":"2002"},{"key":"ref2","series-title":"Biochem Soc Trans","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1042\/BST0351147","article-title":"Biochemistry of oxidative stress","volume":"35","author":"Halliwell","year":"2007"},{"key":"ref3","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"714","DOI":"10.2460\/javma.231.5.714","article-title":"Oxidative stress, antioxidants, and assessment of oxidative stress in dogs and cats","volume":"231","author":"McMichael","year":"2007"},{"key":"ref4","series-title":"J Am Vet Med Assoc","first-page":"644","article-title":"Assessment of degree of oxidative stress and antioxidant concentrations in dogs with idiopathic dilated cardiomyopathy","volume":"215","author":"Freeman","year":"1999"},{"key":"ref5","series-title":"J Hypertens","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1097\/00004872-200018060-00002","article-title":"Role of oxidative stress in cardiovascular diseases","volume":"18","author":"Dhalla","year":"2000"},{"key":"ref6","series-title":"Circulation","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1161\/01.CIR.0000093661.90582.c4","article-title":"Oxidative stress and cardiovascular injury. 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