{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:31:36Z","timestamp":1772839896863,"version":"3.50.1"},"reference-count":47,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Abstract<\/jats:title>\nOBJECTIVE<\/jats:bold> To evaluate the safety and efficacy of oxygen administration by use of a high-flow nasal cannula (HFNC) in sedated clinically normal dogs.<\/jats:p>\nANIMALS<\/jats:bold> 6 healthy adult dogs undergoing routine dental prophylaxis.<\/jats:p>\nPROCEDURES<\/jats:bold> Dogs were sedated with butorphanol tartrate and dexmedetomidine. An esophageal balloon catheter was inserted into the esophagus, a double-pronged nasal cannula was inserted into the nares, and a catheter was inserted into the dorsal pedal artery. Dogs were positioned in right lateral recumbency. After a 6-minute acclimation period, baseline blood gas values and transpulmonary pressure were measured. Dogs then received supplemental oxygen via conventional oxygen therapy (COT) at a rate of 100 mL\/kg\/min (COT-100 treatment) and an HFNC at a rate of 20 L\/min (HF-20 treatment) and 30 L\/min (HF-30 treatment). Arterial blood gas and transpulmonary pressure were measured after a 6-minute acclimation period for each oxygen delivery method. Radiographs were obtained before and after oxygen administration to evaluate gastric distension.<\/jats:p>\nRESULTS<\/jats:bold> Median Pao<\/jats:sc>2<\/jats:sub> was significantly higher for HF-20 (519.9 mm Hg) and HF-30 (538.1 mm Hg) treatments, compared with median Pao2<\/jats:sub> for the COT-100 treatment (202.9 mm Hg). The Pao<\/jats:sc>2<\/jats:sub> did not differ significantly between the HF-20 and HF-30 treatments. There was no significant difference in Paco<\/jats:sc>2<\/jats:sub> or change in transpulmonary pressure between baseline and any oxygen delivery method.<\/jats:p>\nCONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> In this study, HFNC appeared to be a safe and effective method for oxygen delivery to sedated healthy dogs. Further studies are needed to evaluate use of HFNCs for oxygen administration to hypoxemic patients.<\/jats:p>","DOI":"10.2460\/ajvr.78.5.624","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T17:56:14Z","timestamp":1493142974000},"page":"624-630","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of oxygen administration with a high-flow nasal cannula to clinically normal dogs"],"prefix":"10.2460","volume":"78","author":[{"given":"Jennifer L.","family":"Daly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine L.","family":"Guenther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie 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