{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T05:01:30Z","timestamp":1749618090104,"version":"3.38.0"},"reference-count":24,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To investigate systemic changes following low-dosage prednisolone administration in dogs.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 4 healthy purpose-bred adult male Beagles.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> Dogs were administered prednisolone PO at a dosage of 2 mg\/kg\/d for 2 weeks, 1 mg\/kg\/d for 4 weeks, and 0.5 mg\/kg\/d for 3 weeks. Body weight, blood pressure, hepatic size and echogenicity, percentage of vacuolated hepatocytes, serum hepatic enzyme activities and glucose concentration, adrenal gland size, and pancreatic echogenicity were evaluated weekly for 9 weeks.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> The only significant change identified was an increase in hepatic echogenicity, assessed by measuring liver-kidney contrast on ultrasonographic images. Increases in hepatic size and percentage of vacuolated hepatocytes were identified, but values did not differ from baseline values. Similarly, serum hepatic enzyme activities increased, but changes were mild and not significantly different from baseline values. Body weight, pancreatic echogenicity, and serum glucose concentration did not show noticeable changes. Mild systemic hypertension was seen, but blood pressure was not significantly different from the baseline value. Similarly, adrenal gland size steadily decreased during the first 6 weeks and increased again after the prednisolone dosage was decreased to 0.5 mg\/kg\/d. However, mean adrenal gland size was not significantly different from the baseline value at any time.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> Results suggested that in dogs, administration of prednisolone at a low dosage was associated with minimal systemic effects.<\/jats:p>","DOI":"10.2460\/ajvr.78.9.1091","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T13:16:08Z","timestamp":1503580568000},"page":"1091-1097","source":"Crossref","is-referenced-by-count":2,"title":["Body weight, blood pressure, and systemic changes following low-dosage prednisolone administration in dogs"],"prefix":"10.2460","volume":"78","author":[{"given":"Sang-Kwon","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungjo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byunggyu","family":"Cheon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dohyeon","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihye","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"246","DOI":"10.2460\/javma.229.2.246","article-title":"Vacuolar 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Res","first-page":"936","article-title":"Adrenocortical suppression in dogs on daily and alternate-day prednisone administration","volume":"40","author":"Chastain","year":"1979"},{"key":"ref6","series-title":"Am J Vet Res","first-page":"1690","article-title":"Measurement of acoustic backscatter and attenuation in the liver of dogs with experimentally induced steroid hepatopathy","volume":"57","author":"O'Brien","year":"1996"},{"key":"ref7","series-title":"Vet Pathol","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1177\/030098588402100406","article-title":"Prednisone-induced morphologic and chemical changes in the liver of dogs","volume":"21","author":"Fittschen","year":"1984"},{"key":"ref8","series-title":"Textbook of veterinary diagnostic radiology","first-page":"679","article-title":"The liver and spleen","author":"Larson","year":"2013"},{"key":"ref9","series-title":"Vet Radiol Ultrasound","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/j.1740-8261.2012.01992.x","article-title":"Radiographic liver size in Pekingese dogs versus other dog breeds","volume":"54","author":"Choi","year":"2013"},{"key":"ref10","series-title":"J Vet Clin","first-page":"186","article-title":"Comparison of ultrasound histogram in liver, kidney and spleen in Beagle dogs","volume":"22","author":"Lee","year":"2005"},{"key":"ref11","series-title":"J Clin Ultrasound","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/(SICI)1097-0096(199601)24:1<25::AID-JCU4>3.0.CO;2-N","article-title":"Sonographic diagnosis of fatty liver using a histogram technique that compares liver and renal cortical echo amplitudes","volume":"24","author":"Osawa","year":"1996"},{"key":"ref12","series-title":"Vet Q","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1080\/01652176.1998.9694829","article-title":"Comparison of attenuation and liver-kidney contrast of liver ultrasonographs with histology and biochemistry in dogs with experimentally induced steroid hepatopathy","volume":"20","author":"Syakalima","year":"1998"},{"key":"ref13","series-title":"JAMA Intern Med","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1001\/jamainternmed.2013.2737","article-title":"Association of oral glucocorticoid use with an increased risk of acute pancreatitis: a population-based nested case-control study","volume":"173","author":"Sadr-Azodi","year":"2013"},{"key":"ref14","series-title":"Can J Comp Med","first-page":"136","article-title":"Prednisone treatment alters the serum amylase and lipase activities in normal dogs without causing pancreatitis","volume":"48","author":"Fittschen","year":"1984"},{"key":"ref15","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.2460\/ajvr.70.8.1001","article-title":"Stability of canine pancreatic lipase immunoreactivity concentration in serum samples and effects of long-term administration of prednisone to dogs on serum canine pancreatic lipase immunoreactivity concentrations","volume":"70","author":"Steiner","year":"2009"},{"key":"ref16","series-title":"Plumb's veterinary drug handbook","first-page":"600","author":"Plumb","year":"2005"},{"key":"ref17","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/j.1748-5827.2002.tb00019.x","article-title":"Investigation of the role of aldosterone in hypertension associated with spontaneous pituitary-dependent hyperadrenocorticism in dogs","volume":"43","author":"Goy-Thollot","year":"2002"},{"key":"ref18","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/j.1748-5827.1996.tb02358.x","article-title":"Epidemiological study of blood pressure in domestic dogs","volume":"37","author":"Bodey","year":"1996"},{"key":"ref19","series-title":"Vet Q","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1080\/01652176.1998.9694854","article-title":"Obesity in dogs: effects on renal function, blood pressure, and renal disease","volume":"20","author":"Joles","year":"1998"},{"key":"ref20","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.2460\/javma.2005.227.1762","article-title":"Serum 17-\u03b1-hydroxyprogesterone and corticosterone concentrations in dogs with nonadrenal neoplasia and dogs with suspected hyperadrenocorticism","volume":"227","author":"Behrend","year":"2005"},{"key":"ref21","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1136\/vr.162.21.673","article-title":"Evaluation of cortisol precursors for the diagnosis of pituitary-dependent hypercortisolism in dogs","volume":"162","author":"Sieber-Ruckstuhl","year":"2008"},{"key":"ref22","series-title":"Res Vet Sci","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1053\/rvsc.2001.0541","article-title":"Duration of increased serum alkaline phosphatase activity in dogs receiving different glucocorticoid doses","volume":"72","author":"Ginel","year":"2002"},{"key":"ref23","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2460\/javma.2004.224.75","article-title":"Accuracy of ultrasound-guided fine-needle aspiration of the liver and cytologic findings in dogs and cats: 97 cases (1990\u20132000)","volume":"224","author":"Wang","year":"2004"},{"key":"ref24","series-title":"Vet Clin Pathol","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/j.1939-165X.2001.tb00254.x","article-title":"Comparison of liver cytology and biopsy diagnoses in dogs and cats","volume":"30","author":"Roth","year":"2001"}],"container-title":["American Journal of Veterinary 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