{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:09:27Z","timestamp":1775768967871,"version":"3.50.1"},"reference-count":88,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>OBJECTIVE<\/jats:bold>\n                    To investigate cardiac structural and functional changes by tissue Doppler imaging (TDI) and strain imaging in dogs with spontaneous type 1 diabetes mellitus.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>ANIMALS<\/jats:bold>\n                    30 client-owned dogs, of which 10 had normotensive type 1 diabetes mellitus and 20 were healthy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>PROCEDURES<\/jats:bold>\n                    All dogs underwent physical examination, laboratory analyses, standard echocardiography, and TDI.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS<\/jats:bold>\n                    On TDI and strain imaging, transmitral peak early diastolic velocity (E)-to-tissue Doppler\u2013derived peak early diastolic velocity at basal segment (E') of septum ratio, E:lateral E\u2019 ratio, and septal tissue Doppler\u2013derived peak late diastolic velocity at basal segment (A') were significantly higher and the septal E':A\u2019 ratio and lateral longitudinal strain were significantly lower for diabetic dogs than for control dogs. Furthermore, in diabetic dogs, serum glucose and fructosamine concentrations after a 12-hour period of food withholding were positively correlated with regional systolic functional variables (septal and lateral longitudinal strain) and left ventricular filling pressure indices (E:septal E\u2019 and E:lateral E\u2019 ratios) but were negatively correlated with diastolic functional variables (E:transmitral peak late diastolic velocity and septal and lateral E':A\u2019 ratios).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold>\n                    Results indicated that myocardial function in diabetic dogs may be altered before the development of clinical heart-associated signs and that the change may be more readily detected by TDI and strain imaging than by conventional echocardiography. In addition, findings indicated that hyperglycemia could have detrimental effects on myocardial function, independent of hypertension, other cardiac diseases, and left ventricular hypertrophy, in dogs with type 1 diabetes.\n                  <\/jats:p>","DOI":"10.2460\/ajvr.79.10.1035","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T09:09:36Z","timestamp":1537952976000},"page":"1035-1043","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of tissue Doppler ultrasonographic and strain imaging for assessment of myocardial dysfunction in dogs with type 1 diabetes mellitus"],"prefix":"10.2460","volume":"79","author":[{"given":"Yun-Hye","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Am J Epidemiol","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1093\/oxfordjournals.aje.a114031","article-title":"Mortality from coronary heart disease in the Tecumseh study. 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