{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:41:45Z","timestamp":1788928905176,"version":"build-2803163510"},"reference-count":26,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To evaluate the diuretic effects and associated changes in hematologic and plasma biochemical values following SC furosemide administration to water-deprived inland bearded dragons (<jats:italic>Pogona vitticeps<\/jats:italic>).<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 9 bearded dragons.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> In a crossover study design, furosemide (5 or 10 mg\/kg) was administered SC every 12 hours for 4 doses or no treatment (control treatment) was provided for the same period. Food and water were withheld. Body weight was recorded before (baseline) and 12 hours after treatment sessions ended and then after 5 minutes of soaking in a water bath. Blood samples were collected at baseline and 12 hours after treatment sessions ended for various measurements.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> Compared with control values, a significant decrease from baseline in body weight was detected after furosemide treatment at 5 and 10 mg\/kg (mean \u00b1 SD percentage decrease, 5.5 \u00b1 3.2% and 5.2 \u00b1 4.1%, respectively). Soaking resulted in a significant increase in body weight after the 5- and 10-mg\/kg furosemide treatments (mean \u00b1 SD percentage increase, 2.9 \u00b1 1.8% and 5.6 \u00b1 2.5%, respectively), compared with change in body weight after the control treatment (0.7 \u00b1 0.7%). Plasma total solids and total protein concentrations increased significantly with both furosemide treatments, and PCV increased significantly with the 10 mg\/kg treatment only. No significant or relevant differences were identified in plasma osmolarity or uric acid or electrolyte concentrations.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> Furosemide as administered resulted in hemoconcentration and weight loss in bearded dragons, most likely owing to its diuretic effects. With additional research, furosemide could be considered for treatment of congestive heart failure and other conditions requiring diuresis in bearded dragons.<\/jats:p>","DOI":"10.2460\/ajvr.79.11.1204","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T19:07:47Z","timestamp":1540840067000},"page":"1204-1208","source":"Crossref","is-referenced-by-count":12,"title":["Effects of furosemide administration to water-deprived inland bearded dragons (Pogona vitticeps)"],"prefix":"10.2460","volume":"79","author":[{"given":"Lily A.","family":"Parkinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Mans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet Clin North Am Exot Anim Pract","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.cvex.2008.10.001","article-title":"Reptile cardiology","volume":"12","author":"Mitchell","year":"2009"},{"key":"ref2","series-title":"Aust Vet J","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1111\/j.1751-0813.1999.tb13193.x","article-title":"Atrioventricular valvular insufficiency and congestive heart failure in a carpet python","volume":"77","author":"Rishniw","year":"1999"},{"key":"ref3","series-title":"J Herpetol Med Surg","first-page":"90","article-title":"Proposed standardization of the two-dimensional echocardiographic examination in snakes","volume":"16","author":"Schilliger","year":"2006"},{"key":"ref4","series-title":"J Zoo Wildl Med","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1638\/2013-0156R6.1","article-title":"Effect of biometric variables on two-dimensional echocardiographic measurements in the red-tailed boa (Boa constrictor constrictor)","volume":"45","author":"Conceic\u00e3o","year":"2014"},{"key":"ref5","series-title":"(Pogona vitticeps). 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