{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T18:11:53Z","timestamp":1782497513931,"version":"3.54.5"},"reference-count":29,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"s001\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To determine the effect of oral administration of gabapentin (20 mg\/kg) on the minimum alveolar concentration (MAC) of isoflurane in dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>6 healthy adult dogs (3 males and 3 females with a mean \u00b1 SD body weight of 24.8 \u00b1 1.3 kg).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Each dog was anesthetized twice. Dogs were initially assigned to 1 of 2 treatments (gabapentin [20 mg\/kg, PO] followed 2 hours later by anesthesia maintained with isoflurane or anesthesia maintained with isoflurane alone). A minimum of 7 days later, dogs received the other treatment. The MAC of isoflurane was determined by use of an iterative bracketing technique with stimulating electrodes placed in the maxillary buccal mucosa. Hemodynamic variables and vital parameters were recorded at the lowest end-tidal isoflurane concentration at which dogs did not respond to the stimulus. Effect of treatment on outcome variables was analyzed by use of a paired <jats:italic>t<\/jats:italic> test.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Mean \u00b1 SD MAC of isoflurane was significantly lower when dogs received gabapentin and isoflurane (0.71 \u00b1 0.12%) than when dogs received isoflurane alone (0.91 \u00b1 0.26%). Mean reduction in MAC of isoflurane was 20 \u00b1 14%. Hemodynamic variables did not differ significantly between treatments. Mean time to extubation was significantly less when dogs received gabapentin and isoflurane (6 \u00b1 4 minutes) than when dogs received isoflurane alone (23 \u00b1 15 minutes).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s005\">\n<jats:title>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Oral administration of gabapentin 2 hours before anesthesia maintained with isoflurane had a MAC-sparing effect with no effect on hemodynamic variables or vital parameters of dogs.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.80.11.1007","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T17:41:03Z","timestamp":1571852463000},"page":"1007-1009","source":"Crossref","is-referenced-by-count":20,"title":["Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in dogs"],"prefix":"10.2460","volume":"80","author":[{"given":"Brittney A.","family":"Johnson","sequence":"first","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turi K.","family":"Aarnes","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey W.","family":"Wanstrath","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina H.","family":"Ricco Pereira","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Bednarski","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Lerche","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"McLoughlin","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Am Anim Hosp Assoc","doi-asserted-by":"publisher","first-page":"13","DOI":"10.5326\/15473317-35-1-13","article-title":"Complications and mortality 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