{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:52:33Z","timestamp":1787025153957,"version":"build-2736575974"},"reference-count":40,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>OBJECTIVE<\/jats:bold>\n                    To compare bony changes of the third metacarpal bone (MC3) of Thoroughbred racehorse cadavers with (cases) or without (controls) catastrophic condylar fracture by use of standing MRI.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>SAMPLE<\/jats:bold>\n                    140 forelimbs from 26 case horses (both forelimbs) and 88 control horses (single forelimb).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>PROCEDURES<\/jats:bold>\n                    Bone marrow lesions (BMLs), identified as a decrease in T1-weighted (T1W) signal and increases in T2*-weighted (T2*W) and short tau inversion recovery (STIR) signals, and dense bone volume percentage (DBVP), identified as decreases in T1W, T2*W, and STIR signals, in the distopalmar aspect of MC3 were recorded. Logistic regression was used to compare fractured and nonfractured limbs of cases and fractured limbs of cases with randomly selected limbs of controls.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS<\/jats:bold>\n                    Among cases, fractured limbs were significantly more likely to have BMLs (26\/26 [100%]) than were nonfractured limbs (7\/26 [27%]). Fractured limbs of cases were significantly more likely to have BMLs (26\/26 [100%]) than were limbs of controls (6\/88 [7%]). Among cases, there was no significant difference in DBVP between fractured and nonfractured limbs in lateral (26% vs 21%, respectively) or medial (25% vs 20%, respectively) condyles. However, DBVP was significantly greater in fractured limbs of cases than in limbs of controls for lateral (26% vs 16%, respectively) and medial (25% vs 18%, respectively) condyles.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold>\n                    Standing MRI revealed a significantly greater degree of bone change in racehorses with condylar fracture when comparing fractured and nonfractured limbs of case horses and fractured limbs of case horses with randomly selected limbs of control horses.\n                  <\/jats:p>","DOI":"10.2460\/ajvr.80.2.178","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T11:05:18Z","timestamp":1548414318000},"page":"178-188","source":"Crossref","is-referenced-by-count":26,"title":["Association of catastrophic condylar fracture with bony changes of the third metacarpal bone identified by use of standing magnetic resonance imaging in forelimbs from cadavers of Thoroughbred racehorses in the United States"],"prefix":"10.2460","volume":"80","author":[{"given":"John G.","family":"Peloso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah D.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Vogler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Marquis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Hilt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Am Vet Med Assoc","first-page":"92","article-title":"Fatal musculoskeletal injuries incurred during racing and training in Thoroughbreds","volume":"208","author":"Estberg","year":"1996"},{"key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"620","article-title":"Prevalence of, and factors associated with musculoskeletal racing injuries of Thoroughbreds","volume":"204","author":"Peloso","year":"1994"},{"key":"ref3","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1136\/vr.154.16.493","article-title":"Risk of fatal distal limb fracture among Thoroughbreds involved in the five types of racing in the United Kingdom","volume":"154","author":"Parkin","year":"2004"},{"key":"ref4","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"661","DOI":"10.2460\/javma.246.6.661","article-title":"Association of catastrophic biaxial fracture of the proximal sesamoid bones with bony changes of the metacarpophalangeal joint identified by standing magnetic resonance imaging in cadaveric forelimbs of Thoroughbred racehorses","volume":"246","author":"Peloso","year":"2015"},{"key":"ref5","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/j.2042-3306.1999.tb03806.x","article-title":"Structural variation of the distal condyles of the third metacarpal bone and third metatarsal bone in the horse","volume":"31","author":"Riggs","year":"1999"},{"key":"ref6","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/evj.12392","article-title":"The role of catastrophic injury or sudden death of the horse in race-day jockey falls and injuries in California, 2007\u20132012","volume":"48","author":"Hitchens","year":"2016"},{"key":"ref7","series-title":"J Bone Miner Res","first-page":"809","article-title":"Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance","volume":"20","author":"Warden","year":"2005"},{"key":"ref8","series-title":"J Orthop Sports Phys Ther","doi-asserted-by":"publisher","first-page":"749","DOI":"10.2519\/jospt.2014.5334","article-title":"Management and prevention of bone stress injuries in long-distance runners","volume":"44","author":"Warden","year":"2014"},{"key":"ref9","series-title":"J Biomech Eng","first-page":"1","article-title":"Biomechanics and mechanobiology of trabecular bone: a review","volume":"137","author":"Oftadeh","year":"2015"},{"key":"ref10","series-title":"Clin Radiol","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.crad.2007.02.018","article-title":"Stress-related bone injuries with emphasis on MRI","volume":"62","author":"Datir","year":"2007"},{"key":"ref11","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1148\/radiol.16142305","article-title":"Acute and stress-related injuries of bone and cartilage: pertinent anatomy, basic biomechanics, and imaging perspective","volume":"280","author":"Pathria","year":"2016"},{"key":"ref12","series-title":"Phys Med Rehabil Clin N Am","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.pmr.2015.08.008","article-title":"Bone stress injuries in runners","volume":"27","author":"Tenforde","year":"2016"},{"key":"ref13","series-title":"Open Access J Sports Med","first-page":"87","article-title":"Diagnosis, treatment, and rehabilitation of stress fractures in the lower extremity in runners","volume":"6","author":"Kahanov","year":"2015"},{"key":"ref14","series-title":"PM R","doi-asserted-by":"publisher","first-page":"S113","DOI":"10.1016\/j.pmrj.2015.09.019","article-title":"High-risk stress fractures: diagnosis and management","volume":"8","author":"McInnis","year":"2016"},{"key":"ref15","series-title":"Vet Clin North Am Equine Pract","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0749-0739(17)30555-2","article-title":"Pathologic findings and pathogenesis of racetrack injuries","volume":"6","author":"Pool","year":"1990"},{"key":"ref16","series-title":"Bone","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S8756-3282(97)00253-6","article-title":"Subchondral bone failure in an equine model of overload arthrosis","volume":"22","author":"Norrdin","year":"1998"},{"key":"ref17","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.2460\/ajvr.71.10.1148","article-title":"Analysis of the subchondral microarchitecture of the distopalmar aspect of the third metacarpal bone in racing Thoroughbreds","volume":"71","author":"Rubio-Mart\u00ednez","year":"2010"},{"key":"ref18","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/j.2042-3306.1992.tb02831.x","article-title":"An association between complete and incomplete stress fractures of the humerus in racehorses","volume":"24","author":"Stover","year":"1992"},{"key":"ref19","series-title":"Results of 428 nuclear scintigraphic examinations of the musculoskeletal system at a Thoroughbred racetrack","first-page":"84","author":"Arthur","year":"1995"},{"key":"ref20","series-title":"Am J Sports Med","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1177\/0363546513490645","article-title":"Correlation of MRI grading of bone stress injuries with clinical risk factors and return to play: a 5-year prospective study in collegiate track and field athletes","volume":"41","author":"Nattiv","year":"2013"},{"key":"ref21","series-title":"Am J Sports Med","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1177\/036354659502300418","article-title":"Tibial stress reaction in runners. Correlation of clinical symptoms and scintigraphy with a new magnetic resonance imaging grading system","volume":"23","author":"Fredericson","year":"1995"},{"key":"ref22","series-title":"J Clin Diagn Res","first-page":"TC06","article-title":"Study of imaging pattern in bone marrow oedema in MRI in recent knee injuries and its correlation with type of knee injury","volume":"10","author":"Sahoo","year":"2016"},{"key":"ref23","series-title":"Vet Res Commun","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s11259-009-9270-z","article-title":"Use of magnetic resonance imaging in the diagnosis of bone marrow edema in the equine distal limb: six cases","volume":"33","author":"Zani","year":"2009"},{"key":"ref24","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.2042-3306.2011.00389.x","article-title":"Low-field standing magnetic resonance imaging findings of the metacarpo\/metatarsophalangeal joint of racing Thoroughbreds with lameness localized to the region: a retrospective study of 131 horses","volume":"44","author":"Powell","year":"2012"},{"key":"ref25","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1111\/evj.12349","article-title":"Unicortical condylar fracture of the Thoroughbred fetlock: 45 cases (2006\u20132013)","volume":"47","author":"Ramzan","year":"2015"},{"key":"ref26","series-title":"Bone","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/j.bone.2010.07.019","article-title":"Third metacarpal condylar fatigue fractures in equine athletes occurs within previously modeled subchondral bone","volume":"47","author":"Whitton","year":"2010"},{"key":"ref27","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"366","DOI":"10.2746\/042516409X368372","article-title":"Post mortem evaluation of palmar osteochondral disease (traumatic osteochondrosis) of the metacarpo\/metatarsophalangeal joint in Thoroughbred racehorses","volume":"41","author":"Barr","year":"2009"},{"key":"ref28","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1111\/evj.12036","article-title":"Pathological and clinical features associated with palmar\/plantar osteochondral disease of the metacarpo\/metatarsophalangeal joint in Thoroughbred racehorses","volume":"45","author":"Pinchbeck","year":"2013"},{"key":"ref29","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.2042-3306.1983.tb01686.x","article-title":"Current concepts of infectious polyarthritis in foals","volume":"15","author":"Firth","year":"1983"},{"key":"ref30","series-title":"Bonekey Rep","first-page":"755","article-title":"Treatment of bone marrow lesions (bone marrow edema)","volume":"4","author":"Eriksen","year":"2015"},{"key":"ref31","series-title":"Indian J Radiol Imaging","doi-asserted-by":"publisher","first-page":"279","DOI":"10.4103\/0971-3026.137049","article-title":"Bone marrow lesions: a systematic diagnostic approach","volume":"24","author":"Del Grande","year":"2014"},{"key":"ref32","series-title":"Acta Radiol","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1080\/02841850802161023","article-title":"Bone marrow edema: pathophysiology, differential diagnosis, and imaging","volume":"49","author":"Starr","year":"2008"},{"key":"ref33","series-title":"Am J Sports Med","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1177\/0363546515574066","article-title":"Diagnostic accuracy of various imaging modalities for suspected lower extremity stress fractures: a systematic review with evidence-based recommendations for clinical practice","volume":"44","author":"Wright","year":"2016"},{"key":"ref34","series-title":"J Orthop Res","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/S0736-0266(01)00138-3","article-title":"Stiff and strong compressive properties are associated with brittle postyield behavior in equine compact bone material","volume":"20","author":"Les","year":"2002"},{"key":"ref35","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/evj.12544","article-title":"Qualitative assessment of bone density at the distal articulating surface of the third metacarpal in Thoroughbred racehorses with and without condylar fracture","volume":"49","author":"Loughridge","year":"2017"},{"key":"ref36","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/evj.12574","article-title":"Can we use subchondral bone thickness on high-field magnetic resonance images to identify Thoroughbred racehorses at risk of catastrophic lateral condylar fracture?","volume":"49","author":"Tranquille","year":"2017"},{"key":"ref37","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"32","DOI":"10.2460\/ajvr.77.1.32","article-title":"Quantitative comparison of bone mineral density characteristics of the distal epiphysis of third metacarpal bones from Thoroughbred racehorses with or without condylar fracture","volume":"77","author":"Bogers","year":"2016"},{"key":"ref38","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/evj.12312","article-title":"Can high-resolution peripheral quantitative computed tomography imaging of subchondral and cortical bone predict condylar fracture in Thoroughbred racehorses?","volume":"47","author":"Trope","year":"2015"},{"key":"ref39","series-title":"PLoS One","doi-asserted-by":"publisher","first-page":"e101230","DOI":"10.1371\/journal.pone.0101230","article-title":"Computed tomographic imaging of subchondral fatigue cracks in the distal end of 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