{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T09:19:41Z","timestamp":1782119981860,"version":"3.54.5"},"reference-count":20,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To evaluate use of flunixin meglumine as a treatment to postpone ovulation in mares, mare fertility after flunixin meglumine treatment during estrous cycles, and effects of flunixin meglumine on function of the corpus luteum after ovulation.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 13 healthy mares.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> A single-blinded, placebo-controlled, crossover study was conducted. Flunixin meglumine (1.1 mg\/kg, IV, q 24 h) or lactated Ringer solution (placebo treatment) was administered for 2 days to mares with a dominant follicle (\u2265 35 mm in diameter) and behavioral signs of estrus. Mares then were bred by artificial insemination. Number of days to ovulation from initial detection of a follicle \u2265 30 mm in diameter, uterine edema score, and pregnancy were determined by ultrasonography; the examiner was unaware of the treatment of each mare. Serum progesterone concentrations were evaluated 5 and 12 days after ovulation by use of radioimmunoassay.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> Data were available for 45 estrus cycles of the 13 mares. Number of days to ovulation from initial detection of a follicle \u2265 30 mm was not significantly affected by administration of flunixin meglumine versus the placebo. Per-cycle pregnancy rate was not significantly different between flunixin meglumine (20\/24 [83%] breedings) and the placebo (13\/19 [68%] breedings). Flunixin meglumine did not significantly affect behavioral signs of estrus, uterine edema, or serum progesterone concentrations.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> Findings did not support the use of flunixin meglumine to postpone ovulation in mares.<\/jats:p>","DOI":"10.2460\/ajvr.80.3.306","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T15:53:09Z","timestamp":1551109989000},"page":"306-310","source":"Crossref","is-referenced-by-count":4,"title":["Effects of flunixin meglumine on postponement of ovulation in mares"],"prefix":"10.2460","volume":"80","author":[{"given":"Callum G.","family":"Donnelly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny L.","family":"Sones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna C.","family":"Dockweiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Norberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey E.","family":"Norberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon H.","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert O.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Reprod Fertil Suppl","first-page":"297","article-title":"The effect of HCG on duration of oestrus, ovulation time and fertility in mares","volume":"23","author":"Voss","year":"1975"},{"key":"ref2","series-title":"Reprod Domest Anim","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1111\/j.1439-0531.2006.00709.x","article-title":"Successful timing of ovulation using deslorelin (Ovuplant) is labour-saving in mares aimed for single ai with frozen semen","volume":"41","author":"Hemberg","year":"2006"},{"key":"ref3","series-title":"Anim Reprod Sci","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.anireprosci.2007.10.005","article-title":"The efficacy of different hCG dose rates and the effect of hCG treatment on ovarian activity: ovulation, multiple ovulation, pregnancy, multiple pregnancy, synchrony of multiple ovulation; in the mare","volume":"109","author":"Davies Morel","year":"2008"},{"key":"ref4","series-title":"Anim Reprod Sci","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0378-4320(01)00156-7","article-title":"The equine frozen semen industry","volume":"68","author":"Loomis","year":"2001"},{"key":"ref5","series-title":"Anim Reprod Sci","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0378-4320(01)00158-0","article-title":"Management and fertility of mares bred with frozen semen","volume":"68","author":"Samper","year":"2001"},{"key":"ref6","series-title":"Vet J","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.tvjl.2012.12.028","article-title":"Preovulatory progestagen treatment in mares fails to delay ovulation","volume":"197","author":"Canisso","year":"2013"},{"key":"ref7","series-title":"J Reprod Fertil","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1530\/jrf.0.0620283","article-title":"Prostaglandins and follicular functions","volume":"62","author":"Armstrong","year":"1981"},{"key":"ref8","series-title":"Prostaglandins","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/0090-6980(93)90037-8","article-title":"A review\u2014role of eicosanoids in vertebrate ovulation","volume":"46","author":"Murdoch","year":"1993"},{"key":"ref9","series-title":"Anim Reprod Sci","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.anireprosci.2011.07.008","article-title":"The effect of treatment with flunixin meglumine at different times relative to hCG administration on ovulation failure and luteal function in mares","volume":"127","author":"Cuervo-Arango","year":"2011"},{"key":"ref10","series-title":"Reprod Domest Anim","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1439-0531.2011.01796.x","article-title":"The effect of systemic administration of cloprostenol on ovulation in mares treated with a prostaglandin synthetase inhibitor","volume":"47","author":"Cuervo-Arango","year":"2012"},{"key":"ref11","series-title":"Anim Reprod Sci","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.anireprosci.2011.04.003","article-title":"Disruption of periovulatory FSH and LH surges during induced anovulation by an inhibitor of prostaglandin synthesis in mares","volume":"126","author":"Ginther","year":"2011"},{"key":"ref12","series-title":"Theriogenology","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.theriogenology.2010.10.011","article-title":"Systemic treatment with high dose of flunixin-meglumine is able to block ovulation in mares by inducing hemorrhage and luteinisation of follicles","volume":"75","author":"Cuervo-Arango","year":"2011"},{"key":"ref13","series-title":"Theriogenology","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.theriogenology.2011.02.015","article-title":"Follicle and systemic hormone interrelationships during induction of luteinized unruptured follicles with a prostaglandin inhibitor in mares","volume":"76","author":"Cuervo-Arango","year":"2011"},{"key":"ref14","series-title":"Reproduction","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1530\/REP-15-0457","article-title":"The mare as a model for luteinized unruptured follicle syndrome: intrafollicular endocrine milieu","volume":"151","author":"Bashir","year":"2016"},{"key":"ref15","series-title":"Reprod Fertil Dev","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1071\/RD08136","article-title":"Induction of haemorrhagic anovulatory follicles in mares","volume":"20","author":"Ginther","year":"2008"},{"key":"ref16","series-title":"Reprod Domest Anim","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1111\/rda.12586","article-title":"Does clinical treatment with phenylbutazone and meloxicam in the pre-ovulatory period influence the ovulation rate in mares?","volume":"50","author":"Lima","year":"2015"},{"key":"ref17","series-title":"J Vet Pharmacol Ther","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/jvp.12056","article-title":"Effect of body weight on the pharmacokinetics of flunixin meglumine in miniature horses and Quarter Horses","volume":"37","author":"Lee","year":"2014"},{"key":"ref18","series-title":"Equine clinical pharmacology","first-page":"138","article-title":"Chapter 8","author":"Bertone","year":"2014"},{"key":"ref19","series-title":"Am J Vet Res","first-page":"1894","article-title":"Disposition and excretion of flunixin meglumine in horses","volume":"49","author":"Soma","year":"1988"},{"key":"ref20","series-title":"Reprod Fertil Dev","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1071\/RDv25n1Ab12","article-title":"Progesterone supplementation day 3 to 5 postovulation in AI-bred mares","volume":"25","author":"Richard","year":"2013"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/80\/3\/ajvr.80.3.306.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/80\/3\/ajvr.80.3.306.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/80\/3\/ajvr.80.3.306.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T20:43:03Z","timestamp":1696538583000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/80\/3\/ajvr.80.3.306.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":20,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.80.3.306","relation":{},"ISSN":["0002-9645"],"issn-type":[{"value":"0002-9645","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}