{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:13:21Z","timestamp":1788542001434,"version":"build-2803163510"},"reference-count":39,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"s001\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate the clinicopathologic, hemodynamic, and echocardiographic effects of short-term administration of anti-inflammatory dosages of prednisolone to systemically normal cats.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>10 cats with allergic dermatitis and 10 healthy control cats.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Cats with allergic dermatitis were randomly allocated to 2 groups and received 2 dosages of prednisolone (1 and 2 mg\/kg\/d, PO, for 7 days) in a crossover design followed by 9-day tapering and 14-day washout periods. Each prednisolone-treated cat was matched to a healthy control cat on the basis of sex, neuter status, age (\u00b1 1 year), and body weight (\u00b1 10%). Control cats received no treatment during the 35-day observation period. Clinicopathologic, echocardiographic, and hemodynamic variables were measured at baseline (day 0) and predetermined times during and after prednisolone administration and compared within and between the 2 treatment groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Prednisolone-treated cats had expected clinicopathologic alterations (mild increases in neutrophil and monocyte counts and serum concentrations of albumin, cholesterol, and triglycerides) but systolic arterial blood pressure; blood glucose, serum potassium, and cardiac biomarker concentrations; urinary sodium excretion; and echocardiographic variables did not differ significantly from baseline at any time. Statistically significant, albeit clinically irrelevant, increases in blood glucose and N-terminal pro-B-type natriuretic peptide concentrations were observed between baseline and the prednisolone pharmacokinetic steady state (7 days after initiation) only when the 2-mg\/kg dosage was administered.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s005\">\n<jats:title>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Results indicated short-term oral administration of anti-inflammatory dosages of prednisolone did not cause relevant hemodynamic, echocardiographic, or diabetogenic effects in systemically normal cats with allergic dermatitis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.80.8.743","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T18:10:10Z","timestamp":1563991810000},"page":"743-755","source":"Crossref","is-referenced-by-count":14,"title":["Clinicopathologic, hemodynamic, and echocardiographic effects of short-term oral administration of anti-inflammatory doses of prednisolone to systemically normal cats"],"prefix":"10.2460","volume":"80","author":[{"given":"Imal A.","family":"Khelik","sequence":"first","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren J.","family":"Berger","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Mochel","sequence":"additional","affiliation":[{"name":"2Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon-Jung","family":"Seo","sequence":"additional","affiliation":[{"name":"2Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-S\u00e9bastien","family":"Palerme","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy A.","family":"Ware","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011."},{"name":"2Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Ward","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 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