{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:05:09Z","timestamp":1761491109048},"reference-count":21,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"s001\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To investigate the effects of a priming dose of alfaxalone on the total anesthetic induction dose for and cardiorespiratory function of sedated healthy cats.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>8 healthy adult cats.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>For this crossover study, cats were sedated with dexmedetomidine and methadone administered IM. Cats next received a priming induction dose of alfaxalone (0.25 mg\/kg, IV) or saline (0.9% NaCl) solution (0.025 mL\/kg, IV) over 60 seconds and then an induction dose of alfaxalone (0.5 mg\/kg\/min, IV) until orotracheal intubation was achieved. Cardiorespiratory variables were recorded at baseline (immediately prior to priming agent administration), immediately after priming agent administration, after orotracheal intubation, and every 2 minutes until extubation. The total induction dose of alfaxalone was compared between the 2 priming agents.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Mean \u00b1 SD total anesthetic induction dose of alfaxalone was significantly lower when cats received a priming dose of alfaxalone (0.98 \u00b1 0.28 mg\/kg), compared with when cats received a priming dose of saline solution (1.41 \u00b1 0.17 mg\/kg). Mean arterial blood pressure was significantly higher when alfaxalone was used as the priming dose. No cats became apneic or had a hemoglobin oxygen saturation of &lt; 90%. Expired volume per minute was not significantly different between the 2 priming agents.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s005\">\n<jats:title>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Administration of a priming dose of alfaxalone to healthy sedated cats reduced the total dose of alfaxalone needed to achieve orotracheal intubation, maintained mean arterial blood pressure, and did not adversely impact the measured respiratory variables.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.81.11.850","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T12:41:36Z","timestamp":1603802496000},"page":"850-855","source":"Crossref","is-referenced-by-count":2,"title":["Effects of a priming dose of alfaxalone on the total anesthetic induction dose for and cardiorespiratory function of sedated healthy cats"],"prefix":"10.2460","volume":"81","author":[{"given":"Angie","family":"Lagos-Carvajal","sequence":"first","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Queiroz-Williams","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannette","family":"Cremer","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina H.","family":"Ricco Pereira","sequence":"additional","affiliation":[{"name":"2Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Nevarez","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson F.","family":"da Cunha","sequence":"additional","affiliation":[{"name":"3Department of Medicine, College of Veterinary Medicine, Midwestern University, Glendale, AZ 85308."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet 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acepromazine","volume":"40","author":"Robinson","year":"2013"},{"key":"ref14","series-title":"Aust Vet J","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/j.1751-0813.2009.00390.x","article-title":"Clinical evaluation of Alfaxan-CD as an intravenous anaesthetic in young cats","volume":"87","author":"Zaki","year":"2009"},{"key":"ref15","series-title":"Vet Anaesth Analg","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1111\/vaa.12233","article-title":"Pharmacokinetics and pharmacodynamics of propofol with or without 2% benzyl alcohol following a single induction dose administered intravenously in cats","volume":"42","author":"Griffenhagen","year":"2015"},{"key":"ref16","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1177\/1098612X15606494","article-title":"Influence of two administration rates of alfaxalone at induction on its relative potency in cats: a pilot 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question of time","volume":"45","author":"Pascoe","year":"2018"},{"key":"ref21","series-title":"Vet Anaesth Analg","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/vaa.12397","article-title":"Cardiovascular effects of dexmedetomidine, with or without MK-467, following intravenous administration in cats","volume":"44","author":"Pypendop","year":"2017"}],"container-title":["American Journal of Veterinary 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