{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:21:30Z","timestamp":1762608090046},"reference-count":12,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"s001\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To determine the degree of histomorphometric damage in dorsal colon and pelvic flexure biopsy specimens (DCBSs and PFBSs, respectively) obtained from horses with large colon volvulus (LCV) and assess the accuracy of predicting short-term outcome for those horses on the basis of DCBS or PFBS characteristics.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>18 horses with \u2265 360\u00b0 LCV that underwent large colon resection.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>During surgery, biopsy specimens from the dorsal colon resection site and the pelvic flexure (when available) were collected from each horse. Interstitial-to-crypt (I:C) ratio (ratio of the lamina propria space occupied by the interstitium to that occupied by crypts), hemorrhage within the lamina propria (mucosal hemorrhage score [MHS] from 0 to 4), and percentage losses of glandular and luminal epithelium were determined in paired biopsy specimens and compared to determine optimal cutoff values for calculating the accuracy of DCBS and PFBS characteristics to predict short-term outcome (survival or nonsurvival after recovery from surgery).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Paired biopsy specimens were obtained from 17 of the 18 horses. The I:C ratio and percentage glandular epithelial loss differed between DCBSs and PFBSs. For DCBSs, an I:C ratio \u2265 0.9 and MHS \u2265 3 each predicted patient nonsurvival with 77.8% accuracy. For PFBSs, an I:C ratio \u2265 I and MHS \u2265 3 predicted patient nonsurvival with 70.6% and 82.4% accuracy, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s005\">\n<jats:title>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Although different, histomorphometric measurements for either DCBSs or PFBSs could be used to accurately predict short-term outcome for horses with LCV that underwent large colon resection, and arguably PFBSs are easier to collect.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.81.11.899","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T12:41:36Z","timestamp":1603802496000},"page":"899-903","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of histomorphometric characteristics of dorsal colon and pelvic flexure biopsy specimens obtained from horses with large colon volvulus that underwent resection"],"prefix":"10.2460","volume":"81","author":[{"given":"Liara M.","family":"Gonzalez","sequence":"first","affiliation":[{"name":"1Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. True","family":"Baker","sequence":"additional","affiliation":[{"name":"2Peterson and Smith Equine Hospital, Ocala, FL 34474."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faith E.","family":"Hughes","sequence":"additional","affiliation":[{"name":"2Peterson and Smith Equine Hospital, Ocala, FL 34474."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony T.","family":"Blikslager","sequence":"additional","affiliation":[{"name":"2Peterson and Smith Equine Hospital, Ocala, FL 34474."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Callie A.","family":"Fogle","sequence":"additional","affiliation":[{"name":"1Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"342","DOI":"10.2746\/042516408X293529","article-title":"Large colon resection and anastomosis in horses: 52 cases (1996-2006)","volume":"40","author":"Driscoll","year":"2008"},{"key":"ref2","series-title":"Vet Surg","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1111\/j.1532-950X.2008.00449.x","article-title":"Survival and complications after large colon resection and end-to-end anastomosis for strangulating large colon volvulus in seventy-three horses","volume":"37","author":"Ellis","year":"2008"},{"key":"ref3","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/j.2042-3306.2012.00620.x","article-title":"Survival of horses following strangulating large colon volvulus","volume":"45","author":"Suthers","year":"2013"},{"key":"ref4","series-title":"Vet Clin North Am Equine Pract","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0749-0739(17)30243-2","article-title":"Large colon resection","volume":"13","author":"Hughes","year":"1997"},{"key":"ref5","series-title":"Equine Vet J Suppl","first-page":"98","article-title":"Evaluation of uniformity of morphological injury of the large colon following severe colonic torsion","volume":"32","author":"van Hoogmoed","year":"2000"},{"key":"ref6","series-title":"Vet Surg","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1111\/j.1532-950X.2012.00994.x","article-title":"Use of pelvic flexure biopsy scores to predict short-term survival after large colon volvulus","volume":"41","author":"Levi","year":"2012"},{"key":"ref7","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/evj.12273","article-title":"Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013","volume":"47","author":"Gonzalez","year":"2015"},{"key":"ref8","series-title":"Vet Surg","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1532-950X.1998.tb00108.x","article-title":"A modified technique for extensive large colon resection and anastomosis in horses","volume":"27","author":"Hughes","year":"1998"},{"key":"ref9","series-title":"Am J Vet Res","first-page":"801","article-title":"Morphologic alterations observed during experimental ischemia of the equine large colon","volume":"49","author":"Snyder","year":"1988"},{"key":"ref10","series-title":"Vet Surg","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1053\/jvet.2000.17836","article-title":"Use of pelvic flexure biopsies to predict survival after large colon torsion in horses","volume":"29","author":"van Hoogmoed","year":"2000"},{"key":"ref11","series-title":"Am J Physiol Gastrointest Liver Physiol","doi-asserted-by":"publisher","first-page":"G63","DOI":"10.1152\/ajpgi.00112.2013","article-title":"Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research","volume":"308","author":"Gonzalez","year":"2015"},{"key":"ref12","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1111\/evj.12358","article-title":"Duration of disease influences survival to discharge of Thoroughbred mares with surgically treated large colon volvulus","volume":"47","author":"Hackett","year":"2015"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/81\/11\/ajvr.81.11.899.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/81\/11\/ajvr.81.11.899.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/81\/11\/ajvr.81.11.899.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T20:43:33Z","timestamp":1696538613000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/81\/11\/ajvr.81.11.899.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":12,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.81.11.899","relation":{},"ISSN":["0002-9645"],"issn-type":[{"value":"0002-9645","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]}}}