{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T06:19:25Z","timestamp":1773987565917,"version":"3.50.1"},"reference-count":33,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"s001\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To determine the dose of coenzyme Q<jats:sub>10<\/jats:sub> (CoQ<jats:sub>10<\/jats:sub>) needed to achieve at least a 3-fold increase in plasma CoQ<jats:sub>10<\/jats:sub> concentration in dogs with myxomatous mitral valve disease (MMVD) and congestive heart failure (CHF).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>18 dogs with CHF due to MMVD and 12 healthy dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>In a randomized, double-blinded, controlled trial, dogs with MMVD were given 50 or 100 mg of water-soluble CoQ<jats:sub>10<\/jats:sub> (ubiquinone; total daily dose, 100 mg [n = 5] or 200 mg [6]) or a placebo (7), PO, twice a day for 2 weeks in addition to regular cardiac treatment. Plasma CoQ<jats:sub>10<\/jats:sub> concentration was measured in dogs with MMVD before (baseline) and at various time points after supplementation began and in healthy dogs once. Concentrations were compared among and within groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>No significant difference in median baseline plasma CoQ<jats:sub>10<\/jats:sub> concentration was detected between healthy dogs and dogs with MMVD. Fold increases in plasma CoQ<jats:sub>10<\/jats:sub> concentrations ranged from 1.7 to 4.7 and 3.2 to 6.8 for individual dogs in the 100-mg and 200-mg groups, respectively. The change in plasma CoQ<jats:sub>10<\/jats:sub> concentration after supplementation began was significantly higher than in the placebo group at 4 hours and 1 and 2 weeks for dogs in the 200-mg group and at 1 and 2 weeks for dogs in the 100-mg group.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s005\">\n<jats:title>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\n<jats:p>A daily CoQ<jats:sub>10<\/jats:sub> dose of 200 mg was sufficient to achieve at least a 3-fold increase in plasma CoQ<jats:sub>10<\/jats:sub> concentration and may be used in CoQ<jats:sub>10<\/jats:sub> supplementation studies involving dogs with CHF due to MMVD.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.82.4.280","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T18:43:35Z","timestamp":1616697815000},"page":"280-285","source":"Crossref","is-referenced-by-count":4,"title":["Randomized, double-blinded, controlled trial of the effects of coenzyme Q10 supplementation on plasma coenzyme Q10 concentration in dogs with myxomatous mitral valve disease"],"prefix":"10.2460","volume":"82","author":[{"given":"Natalia","family":"Druzhaeva","sequence":"first","affiliation":[{"name":"Small Animal Clinic, University of Ljubljana, 1000 Ljubljana, Slovenia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra Domanjko","family":"Petri\u010d","sequence":"additional","affiliation":[{"name":"Small Animal Clinic, University of Ljubljana, 1000 Ljubljana, Slovenia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrijela","family":"Tav\u010dar-Kalcher","sequence":"additional","affiliation":[{"name":"Institute of Food Safety, Feed and Environment, University of Ljubljana, 1000 Ljubljana, Slovenia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janja","family":"Babi\u010d","sequence":"additional","affiliation":[{"name":"Institute of Food Safety, Feed and Environment, University of Ljubljana, 1000 Ljubljana, Slovenia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alenka","family":"Nemec Svete","sequence":"additional","affiliation":[{"name":"Small Animal Clinic, University of Ljubljana, 1000 Ljubljana, Slovenia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Mitochondrion","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1016\/j.mito.2007.02.006","article-title":"The antioxidant role of coenzyme Q","volume":"7","author":"Bentinger M","year":"2007","unstructured":"Bentinger M, Brismar K, Dallner G. 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