{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T16:34:03Z","timestamp":1763829243942},"reference-count":18,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2021,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"s001\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To characterize the signalment, clinical signs, clinical pathological and histologic findings, and outcome in 8 related Bracchi Italiani with proteinuric kidney disease.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>8 client-owned Bracchi Italiani.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Health records submitted to the Bracco Italiano Health Foundation and the Bracco Italiano Club of America between 2012 and 2019 were reviewed for dogs with evidence of nephropathy for which histologic diagnoses were obtained. Pedigree, signalment, clinical signs, diagnostic test results (including microscopic examination of kidney tissue samples collected ante- or postmortem), and outcome were acquired. Results were presented as descriptive statistics.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The most common clinical sign in affected dogs was inappetence. All dogs were proteinuric, and 4 dogs were azotemic. Seven dogs developed clinical signs of kidney disease and were euthanized a median of 75 days postdiagnosis. Six dogs had glomerular amyloidosis, and 1 dog each had nephrosclerosis and nonamyloidotic fibrillar glomerulopathy.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s005\">\n<jats:title>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Results indicated that the clinical presentation may vary in affected dogs, and proteinuria in young or middle-aged Bracchi Italiani should raise the concern for hereditary nephropathy. Prognosis is likely poor once clinical signs are noted.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.20.07.0420","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T15:38:57Z","timestamp":1636558737000},"page":"1422-1427","source":"Crossref","is-referenced-by-count":5,"title":["Familial nephropathy in Bracchi Italiani: 8 cases (2012\u20132019)"],"prefix":"10.2460","volume":"259","author":[{"given":"Amanda L.","family":"Inman","sequence":"first","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley E.","family":"Allen-Durrance","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel E.","family":"Cianciolo","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Autumn N.","family":"Harris","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610."},{"name":"From the Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"2","key":"ref1","series-title":"J Vet Intern Med.","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1939-1676.2011.00878.x","article-title":"Renal amyloidosis in dogs: a retrospective study of 91 cases with comparison of the disease between Shar-Pei and non-Shar-Pei dogs","volume":"26","author":"Segev G","year":"2012","unstructured":"Segev G, Cowgill LD, Jessen S, Berkowitz A, Mohr CF, Aroch I. Renal amyloidosis in dogs: a retrospective study of 91 cases with comparison of the disease between Shar-Pei and non-Shar-Pei dogs. J Vet Intern Med. 2012;26(2):259\u2013268.10.1111\/j.1939-1676.2011.00878.x"},{"issue":"4","key":"ref2","series-title":"Amyloid.","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1080\/13506129.2018.1549825","article-title":"Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee","volume":"25","author":"Benson MD","year":"2018","unstructured":"Benson MD, Buxbaum JN, Eisenberg DS,  Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee. Amyloid. 2018;25(4):215\u2013219.10.1080\/13506129.2018.1549825"},{"issue":"4","key":"ref3","series-title":"Amyloid.","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1080\/13506129.2016.1257986","article-title":"Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 nomenclature guidelines","volume":"23","author":"Sipe JD","year":"2016","unstructured":"Sipe JD, Benson MD, Buxbaum JN,  Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 nomenclature guidelines. Amyloid. 2016;23(4):209\u2013213.10.1080\/13506129.2016.1257986"},{"issue":"1","key":"ref4","series-title":"Vet Clin North Am Small Anim Pract.","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.cvsm.2010.09.006","article-title":"Protein-losing nephropathy in small animals","volume":"41","author":"Littman MP","year":"2011","unstructured":"Littman MP. Protein-losing nephropathy in small animals. Vet Clin North Am Small Anim Pract. 2011;41(1):31\u201362.10.1016\/j.cvsm.2010.09.006"},{"issue":"4","key":"ref5","series-title":"J Am Vet Med Assoc.","first-page":"569","article-title":"Renal amyloidosis in a family of Beagles","volume":"201","author":"Bowles MH","year":"1992","unstructured":"Bowles MH, Mosier DA. Renal amyloidosis in a family of Beagles. J Am Vet Med Assoc. 1992;201(4):569\u2013574."},{"issue":"6","key":"ref6","series-title":"Can Vet J.","first-page":"631","article-title":"Proteinuria in dogs and cats","volume":"53","author":"Harley L","year":"2012","unstructured":"Harley L, Langston C. Proteinuria in dogs and cats. Can Vet J. 2012;53(6):631\u2013638."},{"issue":"10","key":"ref7","series-title":"PLoS One.","doi-asserted-by":"publisher","first-page":"e75242","DOI":"10.1371\/journal.pone.0075242","article-title":"Thorough investigation of a canine autoinflammatory disease (AID) confirms one main risk locus and suggests a modifier locus for amyloidosis","volume":"8","author":"Olsson M","year":"2013","unstructured":"Olsson M, Tintle L, Kierczak M,  Thorough investigation of a canine autoinflammatory disease (AID) confirms one main risk locus and suggests a modifier locus for amyloidosis. PLoS One. 2013;8(10):e75242. doi: 10.1371\/journal.pone.007524210.1371\/journal.pone.0075242"},{"issue":"1","key":"ref8","series-title":"BMC Genomics.","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1186\/s12864-017-3737-z","article-title":"Whole genome sequencing identifies missense mutation in MTBP in Shar-Pei affected with autoinflammatory disease (SPAID)","volume":"18","author":"Metzger J","year":"2017","unstructured":"Metzger J, Nolte A, Uhde A-K, Hewicker-Trauwein M, Distl O. Whole genome sequencing identifies missense mutation in MTBP in Shar-Pei affected with autoinflammatory disease (SPAID). BMC Genomics. 2017;18(1):348. doi: 10.1186\/s12864-017-3737-z10.1186\/s12864-017-3737-z"},{"key":"ref9","series-title":"International Renal Interest Society","unstructured":"Staging of chronic kidney disease. International Renal Interest Society. Accessed August 11, 2019. www.iris-kidney.com\/pdf\/IRIS_Staging_of_CKD_modified_2019.pdf"},{"key":"ref10","series-title":"J Rheumatol.","first-page":"543704","article-title":"Scleroderma renal crisis: a pathology perspective","volume":"2010","author":"Batal I","year":"2010","unstructured":"Batal I, Domsic RT, Medsger TA, Bastacky S. Scleroderma renal crisis: a pathology perspective. J Rheumatol. 2010;2010:543704. doi: 10.1155\/2010\/543704"},{"issue":"4","key":"ref11","series-title":"Ital J Anim Sci.","doi-asserted-by":"publisher","first-page":"e59","DOI":"10.4081\/ijas.2011.e59","article-title":"Genetic variability of the Bracco Italiano dog breed based on microsatellite polimorphism","volume":"10","author":"Ciampolini R","year":"2011","unstructured":"Ciampolini R, Cecchi F, Bramante A, Casetti F, Presciuttini S. Genetic variability of the Bracco Italiano dog breed based on microsatellite polimorphism. Ital J Anim Sci. 2011;10(4):e59. doi: 10.4081\/ijas.2011.e5910.4081\/ijas.2011.e59"},{"issue":"4","key":"ref12","series-title":"J Vet Intern Med.","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1111\/jvim.12090","article-title":"Chronic kidney disease in dogs in UK veterinary practices: prevalence, risk factors, and survival","volume":"27","author":"O'Neill DG","year":"2013","unstructured":"O'Neill DG, Elliott J, Church DB, McGreevy PD, Thomson PC, Brodbelt DC. Chronic kidney disease in dogs in UK veterinary practices: prevalence, risk factors, and survival. J Vet Intern Med. 2013;27(4):814\u2013821.10.1111\/jvim.12090"},{"issue":"4","key":"ref13","series-title":"Clin J Am Soc Nephrol.","doi-asserted-by":"publisher","first-page":"775","DOI":"10.2215\/CJN.08300910","article-title":"Fibrillary glomerulonephritis: a report of 66 cases from a single institution","volume":"6","author":"Nasr SH","year":"2011","unstructured":"Nasr SH, Valeri AM, Cornell LD,  Fibrillary glomerulonephritis: a report of 66 cases from a single institution. Clin J Am Soc Nephrol. 2011;6(4):775\u2013784.10.2215\/CJN.08300910"},{"issue":"18","key":"ref14","series-title":"Chin Med J (Engl).","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.4103\/0366-6999.213970","article-title":"Fibronectin glomerulopathy: a rare autosomal dominant glomerular disease","volume":"130","author":"Wu J","year":"2017","unstructured":"Wu J, Zhou Y, Huang X, Huang L, Tang Z. Fibronectin glomerulopathy: a rare autosomal dominant glomerular disease. Chin Med J (Engl). 2017;130(18):2261\u20132262.10.4103\/0366-6999.213970"},{"key":"ref15","series-title":"BMC Nephrol.","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1471-2369-4-6","article-title":"Familial Mediterranean fever, inflammation and nephrotic syndrome: fibrillary glomerulopathy and the M6801 missense mutation","volume":"4","author":"Fisher PW","year":"2003","unstructured":"Fisher PW, Ho LT, Goldschmidt R, Semerdian RJ, Rutecki GW. Familial Mediterranean fever, inflammation and nephrotic syndrome: fibrillary glomerulopathy and the M6801 missense mutation. BMC Nephrol. 2003;4:6. doi: 10.1186\/1471-2369-4-610.1186\/1471-2369-4-6"},{"issue":"2","key":"ref16","series-title":"Kidney Int.","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/ki.1992.57","article-title":"Spectrum of renal involvement in familial Mediterranean fever","volume":"41","author":"Said R","year":"1992","unstructured":"Said R, Hamzeh Y, Said S, Tarawneh M, al-Khateeb M. Spectrum of renal involvement in familial Mediterranean fever. Kidney Int. 1992;41(2):414\u2013419.10.1038\/ki.1992.57"},{"issue":"4","key":"ref17","series-title":"Turk J Pediatr.","first-page":"317","article-title":"Tubular functions in familial Mediterranean fever","volume":"44","author":"Akku\u015f S","year":"2002","unstructured":"Akku\u015f S, Cali\u015fkan S, Kasap\u00e7opur O. Tubular functions in familial Mediterranean fever. Turk J Pediatr. 2002;44(4):317\u2013320."},{"issue":"1","key":"ref18","series-title":"Arch Dis Child.","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1136\/adc.70.1.27","article-title":"Serum concentration and urinary excretion of \u03b22-microglobulin and microalbuminuria in familial Mediterranean fever","volume":"70","author":"Saatci U","year":"1994","unstructured":"Saatci U, Ozdemir S, Ozen S, Bakkaloglu A. Serum concentration and urinary excretion of \u03b22-microglobulin and microalbuminuria in familial Mediterranean fever. 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