{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:20:01Z","timestamp":1779877201448,"version":"3.53.1"},"reference-count":31,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2022,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To describe the association between a diagnosis of eosinophilic lung disease (ELD) in dogs with signalment and bronchoscopic features and evaluate the accuracy of visualization of nodules for the diagnosis of ELD.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>781 dogs with cough that underwent bronchoscopy between 2014 and 2016.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Data were extracted from the medical records of each included dog. Multivariable logistic regression was performed to investigate associations between ELD and patient characteristics.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>ELD was diagnosed in 113 (14.5%) dogs. More than 3 nodular lesions of the bronchial mucosa were detected in 64 (8.2%) dogs. The odds of having ELD were greater in dogs with nodules (adjusted OR [aOR], 26.0; 95% CI, 13.0 to 52.0) and static bronchial collapse (aOR, 2.3; 95% CI, 1.1 to 4.6), and lower in dogs having focal versus diffuse inflammation (aOR, 0.05; 95% CI, 0.01 to 0.37). The odds of having ELD decreased for each 1-year increase in age (aOR, 0.86; 95% CI, 0.80 to 0.92), and increased for each 1-kg increase in weight (aOR, 1.04; 95% CI, 1.01 to 1.06). Visualization of nodules during bronchoscopy had a overall accuracy of 89.4% (95% CI, 87.0% to 91.4%), sensitivity of 41.6% (32.4% to 51.2%), and specificity of 97.5% (96.0% to 98.5%) for a diagnosis of ELD.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>On the basis of high specificity and negative predictive value, lack of visualization of bronchial nodules during bronchoscopy can be used to preliminarily rule out ELD. However, visualization of bronchial nodules does not imply presence of ELD. This could be especially relevant when results of BAL cytology are available several days after the actual bronchoscopy.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.20.10.0559","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T18:49:52Z","timestamp":1641322192000},"page":"414-421","source":"Crossref","is-referenced-by-count":3,"title":["Presence of bronchial nodules, younger age, and heavier body weight are associated with a diagnosis of eosinophilic lung disease in dogs with cough"],"prefix":"10.2460","volume":"260","author":[{"given":"Enrico","family":"Bottero","sequence":"first","affiliation":[{"name":"Endovet Professional Association, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Ruggiero","sequence":"additional","affiliation":[{"name":"Endovet Professional Association, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Benvenuti","sequence":"additional","affiliation":[{"name":"Endovet Professional Association, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Mussi","sequence":"additional","affiliation":[{"name":"Endovet Professional Association, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Falcioni","sequence":"additional","affiliation":[{"name":"Endovet Professional Association, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"De Lorenzi","sequence":"additional","affiliation":[{"name":"Veterinary Hospital I Portoni Rossi, Zola Pedrosa, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Di Girolamo","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"R1","series-title":"J Vet Intern Med","first-page":"282","article-title":"Eosinophilic bronchopneumopathy in dogs","volume":"14","author":"Clercx C","year":"2000","unstructured":"Clercx C, Peeters D, Snaps F,  Eosinophilic bronchopneumopathy in dogs. 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Vet Rec. 2020;187(8):e65.32661182"},{"key":"R4","series-title":"J Vet Intern Med","first-page":"2217","article-title":"Eosinophilic bronchitis, eosinophilic granuloma, and eosinophilic bronchopneumopathy in 75 dogs (2006\u20132016)","volume":"33","author":"Johnson LR","year":"2019","unstructured":"Johnson LR, Johnson EG, Hulsebosch SE,  Eosinophilic bronchitis, eosinophilic granuloma, and eosinophilic bronchopneumopathy in 75 dogs (2006\u20132016). J Vet Intern Med. 2019;33:2217\u20132226.31468629"},{"key":"R5","series-title":"J Comp Pathol","first-page":"128","article-title":"Distribution of leucocyte subsets in bronchial mucosa from dogs with eosinophilic bronchopneumopathy","volume":"133","author":"Peeters D","year":"2005","unstructured":"Peeters D, Day MJ, Clercx C. Distribution of leucocyte subsets in bronchial mucosa from dogs with eosinophilic bronchopneumopathy. J Comp Pathol. 2005;133:128\u2013135.16026798"},{"key":"R6","series-title":"Parasit Vectors","first-page":"62","article-title":"Canine and feline cardiopulmonary parasitic nematodes in Europe: emerging and underestimated","volume":"3","author":"Traversa D","year":"2010","unstructured":"Traversa D, Di Cesare A, Conboy G. Canine and feline cardiopulmonary parasitic nematodes in Europe: emerging and underestimated. Parasit Vectors. 2010;3:62. doi: 10.1186\/1756-3305-3-6220653938"},{"key":"R7","series-title":"J Small Anim Pract","first-page":"435","article-title":"Angiostrongylus vasorum infection in 23 dogs (1999\u20132002)","volume":"45","author":"Chapman PS","year":"2004","unstructured":"Chapman PS, Boag AK, Guitian J, Boswood A. Angiostrongylus vasorum infection in 23 dogs (1999\u20132002). J Small Anim Pract. 2004;45:435\u2013440.15460201"},{"key":"R8","series-title":"Vet J","first-page":"52","article-title":"Detection of specific bacterial agents by quantitative PCR assays in the bronchoalveolar lavage fluid of dogs with eosinophilic bronchopneumopathy vs. dogs with chronic bronchitis and healthy dogs","volume":"232","author":"Canonne AM","year":"2018","unstructured":"Canonne AM, Peters I, Roels E, Desquilbet L, Clercx C. Detection of specific bacterial agents by quantitative PCR assays in the bronchoalveolar lavage fluid of dogs with eosinophilic bronchopneumopathy vs. dogs with chronic bronchitis and healthy dogs. Vet J. 2018;232:52\u201356.29428092"},{"key":"R9","series-title":"BMJ","first-page":"e3999","article-title":"Interpreting diagnostic accuracy studies for patient care","volume":"345","author":"Mallett S","year":"2012","unstructured":"Mallett S, Halligan S, Thompson M, Collins GS, Altman DG. Interpreting diagnostic accuracy studies for patient care. 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Chest. 1983;84:774\u2013776.6641316"},{"issue":"7","key":"R21","series-title":"Eur Respir J","first-page":"1237","article-title":"Inflammatory bronchial polyps associated with asthma: resolution with inhaled corticosteroid","volume":"8","author":"Niimi A","year":"1995","unstructured":"Niimi A, Amitani R, Ikeda T, Kubo Y, Tanaka E, Kuze F. Inflammatory bronchial polyps associated with asthma: resolution with inhaled corticosteroid. Eur Respir J. 1995;8(7):1237\u20131239.7589412"},{"key":"R22","series-title":"Vet Pathol","first-page":"372","article-title":"Gammaherpesviruses and pulmonary fibrosis: evidence from humans, horses, and rodents","volume":"51","author":"Williams KJ","year":"2014","unstructured":"Williams KJ. Gammaherpesviruses and pulmonary fibrosis: evidence from humans, horses, and rodents. Vet Pathol. 2014;51:372\u2013384.24569614"},{"issue":"4","key":"R23","series-title":"Equine Vet Educ","first-page":"200","article-title":"Pulmonary fibrosis and gammaherpesvirus infection in horses","volume":"24","author":"Dunkel B","year":"2012","unstructured":"Dunkel B. Pulmonary fibrosis and gammaherpesvirus infection in horses. Equine Vet Educ. 2012;24(4):200\u2013205."},{"issue":"3","key":"R24","series-title":"J Vet Intern Med","first-page":"648","article-title":"Idiopathic chronic eosinophilic pneumonia in 7 horses","volume":"22","author":"Bell SA","year":"2008","unstructured":"Bell SA, Drew CP, Wilson WD, Pusterla N. Idiopathic chronic eosinophilic pneumonia in 7 horses. J Vet Intern Med. 2008;22(3):648\u2013653.18466259"},{"key":"R25","article-title":"Textbook of Special Pathological Anatomy of Domestic Animals","author":"Cohrs P","year":"2013","unstructured":"Cohrs P. Textbook of Special Pathological Anatomy of Domestic Animals. 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