{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T02:45:45Z","timestamp":1782355545518,"version":"3.54.5"},"reference-count":9,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2000,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine epidemiologic characteristics,\nclinical findings, and treatment outcome of 5-hydroxytryptophan (5-HTP) toxicosis in dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Retrospective study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201421 dogs with evidence of accidental 5-HTP\ningestion.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Information was retrieved from the\nNational Animal Poison Control Center database.\nRecords of dogs ingesting 5-HTP between January\n1989 and February 1999 were reviewed for information\non signalment, dose ingested, clinical signs\n(onset, severity, duration), treatments administered,\nand outcome.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Clinical signs of toxicosis developed in 19 of\n21 (90%) dogs. Neurologic signs included seizures (9\ndogs), depression (6), tremors (5), hyperesthesia (5),\nand ataxia (4). Gastrointestinal tract signs included\nvomiting or diarrhea (12 dogs), signs of abdominal\npain (3), and hypersalivation (2). Other clinical signs\nwere hyperthermia (7 dogs) and transient blindness\n(3). Three dogs died. No important clinical laboratory\nor necropsy findings were reported. The doses of 5-HTP ingested ranged from 2.5 to 573 mg\/kg (1.1 to\n260 mg\/lb) of body weight; the minimum toxic dose\nreported in our study was 23.6 mg\/kg (10.7 mg\/lb),\nand the minimum lethal dose was 128 mg\/kg (58.1\nmg\/lb). Onset of signs ranged from 10 minutes to 4\nhours after ingestion, and signs lasted up to 36 hours.\nOf 17 dogs with clinical signs of toxicosis that\nreceived treatment, 16 recovered; treatment consisted\nof decontamination, seizure control, thermoregulation,\nfluid therapy, and supportive care.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Ingestion of\n5-HTP in dogs can result in a potentially life-threatening\nsyndrome resembling serotonin syndrome in\nhumans, which requires prompt and aggressive care.\n(<jats:italic>J Am Vet Med Assoc<\/jats:italic> 2000;216:1937\u20131940)<\/jats:p>","DOI":"10.2460\/javma.2000.216.1937","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T17:41:34Z","timestamp":1133890894000},"page":"1937-1940","source":"Crossref","is-referenced-by-count":66,"title":["5-Hydroxytryptophan toxicosis in dogs: 21 cases (1989\u20131999)"],"prefix":"10.2460","volume":"216","author":[{"given":"Sharon M.","family":"Gwaltney-Brant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay C.","family":"Albretsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safdar A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"p_1_1","first-page":"271","volume":"3","author":"Birdsall TC.","year":"1998","journal-title":"Altern Med Rev"},{"key":"p_2_2","first-page":"249","author":"Sanders-Bush E","year":"1996","journal-title":"New York: McGraw-Hill Book Co Inc"},{"key":"p_3_3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1600-0773.1980.tb02451.x","volume":"46","author":"Magnussen IE","year":"1980","journal-title":"Acta Pharmacol Toxicol"},{"key":"p_4_4","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199513020-00004"},{"key":"p_5_5","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0704(05)70368-7"},{"key":"p_6_6","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(98)00057-2"},{"key":"p_7_7","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00086-7"},{"key":"p_8_8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)06457-0"},{"key":"p_9_9","unstructured":"Plumb DC. Veterinary drug handbook. 3rd ed. Ames, Iowa: Iowa State University Press, 1999;186-187, 496-498, 164-165."}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/216\/12\/javma.2000.216.1937.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/216\/12\/javma.2000.216.1937.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/216\/12\/javma.2000.216.1937.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:45:07Z","timestamp":1741355107000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/216\/12\/javma.2000.216.1937.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6,15]]},"references-count":9,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.2460\/javma.2000.216.1937","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2000,6,15]]}}}