{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:28:38Z","timestamp":1778279318369,"version":"3.51.4"},"reference-count":16,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To compare outcome and intermediateterm\nsurvival for dogs undergoing open surgical correction\nof subvalvular aortic stenosis (SAS) with those\nfor dogs with SAS that did not undergo surgery.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Retrospective study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201444 dogs with congenital SAS.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Maximum instantaneous systolic pressure\ngradients were determined by use of Doppler\nechocardiography. Cardiopulmonary bypass and open\nsurgical correction of SAS (membranectomy with or\nwithout septal myectomy) was performed in 22 dogs,\nwhereas 22 dogs did not undergo surgical correction.\nCumulative survival was compared between surgical\nand nonsurgical groups, using Kaplan-Meier nonparametric\nanalysis and a Mantel-Cox log-rank test.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Initial systolic pressure gradients were not\nsignificantly different for dogs undergoing surgery (128\n\u00b1 55 mm Hg), compared with those that did not undergo\nsurgery (117 \u00b1 57 mm Hg). Systolic pressure gradients\nwere significantly decreased after surgery in\ndogs that underwent surgery (54 \u00b1 27 mm Hg).\nCumulative survival was not significantly different\nbetween dogs in the surgical and nonsurgical groups.\nCensoring surgery-related mortality in the analysis still\ndid not reveal a significant difference in cumulative survival\nbetween the surgical and nonsurgical groups.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusion and Clinical Relevance<\/jats:bold>\u2014Despite\nreductions in the systolic pressure gradient and possible\nassociated improvement in exercise tolerance, a\npalliative benefit on survival was not documented in\ndogs undergoing surgery for SAS. 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