{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:52:24Z","timestamp":1760079144540,"version":"3.38.0"},"reference-count":11,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2000,1,1]]},"abstract":"Abstract<\/jats:title>\n\t\t\t\t\n\t\t\t\t\tObjective<\/jats:bold>\u2014To determine the efficacy of florfenicol\nfor treatment of calves with naturally occurring infectious\nbovine keratoconjunctivitis (IBK).<\/jats:p>\n\t\t\t\t\n\t\t\t\t\tDesign<\/jats:bold>\u2014Randomized controlled field trial.<\/jats:p>\n\t\t\t\t\n\t\t\t\t\tAnimals<\/jats:bold>\u201463 beef calves and 80 dairy calves\nbetween 4 and 12 months of age.<\/jats:p>\n\t\t\t\t\n\t\t\t\t\tProcedure<\/jats:bold>\u2014Calves were randomly assigned to 1 of 3\ntreatment groups. Calves in the SC treatment group\nreceived a single dose of florfenicol (40 mg\/kg [18.2\nmg\/lb] of body weight), SC, on day 0. Calves in the IM\ntreatment group received florfenicol (20 mg\/kg [9.1\nmg\/lb]), IM, on days 0 and 2. Calves in the control\ngroup received injections of saline solution (0.9%\nNaCl), IM, on days 0 and 2. Calves were reevaluated\nevery other day for 20 days after treatment.<\/jats:p>\n\t\t\t\t\n\t\t\t\t\tResults<\/jats:bold>\u2014Corneal ulcers healed by day 20 in 48 of 49\n(98%) calves treated with florfenicol IM, 39 of 42\n(93%) calves treated with florfenicol SC, and 33 of 52\n(63%) control calves.<\/jats:p>\n\t\t\t\t\n\t\t\t\t\tConclusions and Clinical Relevance<\/jats:bold>\u2014Florfenicol\nadministered SC (1 dose) or IM (2 doses 48 hours\napart) was effective for treatment of calves with naturally\noccurring IBK. ( J Am Vet Med Assoc<\/jats:italic> 2000;216:\n62\u201364)<\/jats:p>","DOI":"10.2460\/javma.2000.216.62","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T17:26:19Z","timestamp":1133889979000},"page":"62-64","source":"Crossref","is-referenced-by-count":34,"title":["Efficacy of florfenicol for treatment of naturally occurring infectious bovine keratoconjunctivitis"],"prefix":"10.2460","volume":"216","author":[{"given":"John A.","family":"Angelos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica L.","family":"Dueger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisle W.","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracey K.","family":"Carrier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy E.","family":"Mihalyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sallie B.","family":"Cosgrove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1_138","first-page":"133","volume":"87","author":"Lavy E","year":"1991","journal-title":"Acta Vet Scand"},{"key":"p_2_139","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-2885.1986.tb00062.x","volume":"9","author":"Varma KJ","year":"1986","journal-title":"J Vet Pharmacol Ther"},{"key":"p_3_140","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1128\/AAC.41.9.1991","volume":"41","author":"de Craene BA","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"p_4_141","doi-asserted-by":"crossref","first-page":"960","DOI":"10.2460\/ajvr.1999.60.08.960","volume":"60","author":"Dueger EL","year":"1999","journal-title":"Am J Vet Res"},{"key":"p_5_142","doi-asserted-by":"crossref","first-page":"376","DOI":"10.2460\/ajvr.1990.51.03.376","volume":"51","author":"Daigneault J","year":"1990","journal-title":"Am J Vet Res"},{"key":"p_6_143","first-page":"392","author":"Weyant RS","year":"1996","journal-title":"Baltimore: The Williams & Wilkins Co"},{"key":"p_7_144","first-page":"6","author":"Jorgensen JH","year":"1997","journal-title":"Pa: NCCLS"},{"key":"p_8_145","first-page":"1415","volume":"192","author":"George L","year":"1988","journal-title":"J Am Vet Med Assoc"},{"key":"p_9_146","first-page":"804","volume":"46","author":"Smith JA","year":"1985","journal-title":"Am J Vet Res"},{"key":"p_10_147","unstructured":"Arrioja-Dechert A, ed. 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