{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:11:44Z","timestamp":1790745104208,"version":"4.1.0"},"reference-count":28,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2000,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine clinical findings, cytologic\nand histologic characteristics of salivary glands, and\nresponse to treatment with phenobarbital in dogs\nwith clinical signs typical of sialadenosis.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Prospective study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201413 dogs with enlarged salivary glands.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Data were collected from dogs with clinical\nsigns attributable to enlarged salivary glands.\nSalivary gland biopsy and cytologic specimens were\nexamined. Dogs were treated with phenobarbital and\nmonitored for response to treatment.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Clinical signs commonly associated with\nsialadenosis included retching and gulping. Substantial\ncellular changes were not detected by histologic\nor cytologic examination of enlarged salivary\nglands. Response to treatment with phenobarbital\nwas rapid, although most dogs required continuous\ntreatment to prevent recurrence of clinical signs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Sialadenosis\nis a condition of unknown cause that may have been\nunderdiagnosed in dogs. Criteria for diagnosis include\ntypical clinical signs, enlarged salivary glands, and lack\nof substantial microscopic lesions. Response to treatment\nwith phenobarbital is rapid. 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