{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:58:22Z","timestamp":1770217102485,"version":"3.49.0"},"reference-count":48,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2000,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine clinical and clinicopathologic\nfeatures of a chronic intermittent severe hemolytic\nanemia characterized by erythrocyte osmotic fragility\nin Abyssinian and Somali cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Case series.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201413 Abyssinian and 5 Somali cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedures<\/jats:bold>\u2014History, pedigree information, and\nresults of routine laboratory tests, special erythrocyte\nstudies, and histologic evaluation of splenic and\nhepatic specimens were analyzed.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Age at which clinical signs of anemia were\nfirst apparent ranged from 6 months to 5 years. Ten\ncats had splenomegaly. Most often, the PCV was\nbetween 15 and 25%, but it was as low as 5% at some\ntimes. The anemia was characterized by macrocytosis\nand mild to moderate reticulocytosis, but no poikilocytosis.\nHyperglobulinemia, lymphocytosis, mild hyperbilirubinemia,\nand high hepatic enzyme activities were\ncommon findings. Results of Coombs tests and tests\nfor infectious diseases were negative. The erythrocytic\nosmotic fragility was high in affected cats (mean\nosmotic fragility, 0.66 to 0.78%), compared with\nhealthy cats (0.48 to 0.58). No specific membrane protein\nabnormality, erythrocyte enzyme deficiency, or\nhemoglobinopathy was identified. Histologic evaluation\nof splenic and hepatic specimens revealed\nextramedullary hematopoiesis and hemosiderosis.\nFour of the 5 Somali cats were closely related.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014On the basis of\nresults of pedigree analyses, the apparent breed\npredilection, and the exclusion of other known causes of\nanemia in cats, we believe that the hemolytic anemia in\nthese cats was likely a result of a novel hereditary erythrocyte\ndefect. A genetic predisposition to immunemediated\ndestruction of erythrocytes could not be ruled\nout. 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