{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:43:22Z","timestamp":1782776602879,"version":"3.54.5"},"reference-count":20,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2000,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate effects of medetomidine on\nanesthetic dose requirements, cardiorespiratory\nvariables, plasma cortisol concentrations, and behavioral\npain scores in dogs undergoing ovariohysterectomy.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Randomized, prospective study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201412 healthy Walker-type hound dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Dogs received medetomidine (40 \u00b5g\/kg\n[18.2 \u00b5g\/lb] of body weight, IM; n = 6) or saline (0.9%\nNaCl) solution (1 ml, IM; 6) prior to anesthesia induction\nwith thiopental; thiopental dose needed for endotracheal\nintubation was compared between groups.\nOvariohysterectomy was performed during halothane\nanesthesia. Blood samples were obtained at various\ntimes before drug administration until 300 minutes\nafter extubation. Various physiologic measurements\nand end-tidal halothane concentrations were recorded.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014In medetomidine-treated dogs, heart rate\nwas significantly lower than in controls, and blood\npressure did not change significantly from baseline.\nPlasma cortisol concentrations did not increase significantly\nuntil 60 minutes after extubation in medetomidine-treated dogs, whereas values in control dogs\nwere increased from time of surgery until the end of\nthe recording period. Control dogs had higher pain\nscores than treated dogs from extubation until the\nend of the recording period.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusion and Clinical Relevance<\/jats:bold>\u2014Administration\nof medetomidine reduced dose requirements for\nthiopental and halothane and provided postoperative\nanalgesia up to 90 minutes after extubation. Dogs\nundergoing ovariohysterectomy by use of thiopental\ninduction and halothane anesthesia benefit from analgesia\ninduced by medetomidine administered prior to\nanesthesia induction. Additional analgesia is appropriate\n60 minutes after extubation. (<jats:italic>J Am Vet Med Assoc<\/jats:italic>\n2000;217:509\u2013514)<\/jats:p>","DOI":"10.2460\/javma.2000.217.509","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T17:43:06Z","timestamp":1133890986000},"page":"509-514","source":"Crossref","is-referenced-by-count":35,"title":["Cardiorespiratory responses and plasma cortisol concentrations in dogs treated with medetomidine before undergoing ovariohysterectomy"],"prefix":"10.2460","volume":"217","author":[{"given":"Jeff C. 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