{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:55:10Z","timestamp":1793130910403,"version":"4.5.0"},"reference-count":33,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2000,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To document the clinical, clinicopathologic,\nand pathologic findings in cats with severe sepsis,\nidentify abnormalities unique to this species, and\nidentify criteria that could be used antemortem to\ndiagnose the systemic inflammatory response syndrome\nin cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Retrospective study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201429 cats confirmed to have severe sepsis at\nnecropsy.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Pertinent history, physical examination\nfindings, and results of hematologic and biochemical\ntesting were extracted from medical records.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Clinical diagnoses included pyothorax, septic\nperitonitis, bacteremia secondary to gastrointestinal\ntract disease, pneumonia, endocarditis,\npyelonephritis, osteomyelitis, pyometra, and bite\nwounds. Physical examination findings included\nlethargy, pale mucous membranes, poor pulse quality,\ntachypnea, hypo- or hyperthermia, signs of diffuse\npain on abdominal palpation, bradycardia, and icterus.\nClinicopathologic abnormalities included anemia,\nthrombocytopenia, band neutrophilia, hypoalbuminemia,\nlow serum alkaline phosphatase activity, and\nhyperbilirubinemia. Necropsy findings included multiorgan\nnecrosis or inflammation with intralesional bacteria.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggest\nthat severe sepsis in cats is characterized by\nlethargy, pale mucous membranes, signs of diffuse\nabdominal pain, tachypnea, bradycardia, weak pulses,\nanemia, hypoalbuminemia, hypothermia, and icterus.\nRecognition of this combination of clinical findings\nshould facilitate the diagnosis of severe sepsis in\ncats. 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