{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:32:22Z","timestamp":1778279542881,"version":"3.51.4"},"reference-count":49,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2001,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine the effect of hydroxyethyl\nstarch (HES) on colloid oncotic pressure (\u03c0) during\nfluid resuscitation of hypoproteinemic horses and to\nevaluate the clinical usefulness of direct and indirect\nmethods for determination of \u03c0 before and after infusion\nof a synthetic colloid.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Prospective clinical study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201411 hypoproteinemic horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Horses received IV infusions of 8 to 10\nml of a 6% solution of HES\/kg (3.6 to 4.5 ml\/lb) of\nbody weight during fluid resuscitation. Blood samples\nwere obtained for determination of plasma measured\ncolloid oncotic pressure (\u03c0<jats:sub>meas<\/jats:sub>) and plasma total protein\nand albumin (A) concentrations. Plasma globulin\nconcentration (G) was calculated as the difference\nbetween plasma total protein and albumin concentrations.\nCalculated values for colloid oncotic pressure\n(\u03c0<jats:sub>A + G<\/jats:sub>) were determined by use of a predictive nomogram\npreviously developed for horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014There was no significant difference\nbetween the means of \u03c0<jats:sub>meas<\/jats:sub> and \u03c0<jats:sub>A + G<\/jats:sub> at the beginning\nof HES infusion. After HES infusion, the mean of\n\u03c0<jats:sub>meas<\/jats:sub> was increased significantly from baseline for 6\nhours. Mean plasma total protein and albumin concentrations\nand \u03c0<jats:sub>A + G<\/jats:sub> were decreased significantly\nfrom baseline for 24 hours. Differences between\nmean \u03c0<jats:sub>meas<\/jats:sub> and \u03c0<jats:sub>A + G<\/jats:sub> after HES infusion were significant\nfor 24 hours.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014There was\ngood agreement between plasma \u03c0<jats:sub>meas<\/jats:sub> and \u03c0<jats:sub>A + G<\/jats:sub> in\nblood samples obtained from hypoproteinemic horses\nimmediately before infusion of HES. Use of a predictive\nnomogram did not, however, account for the\noncotic effect of HES. Results of comparison of \u03c0<jats:sub>meas<\/jats:sub>\nto \u03c0<jats:sub>A + G<\/jats:sub> after HES infusion suggest that a significant\noncotic effect was maintained for 24 hours in the\nstudy horses. (<jats:italic>J Am Vet Med Assoc<\/jats:italic> 2001;218:\n1130\u20131135)<\/jats:p>","DOI":"10.2460\/javma.2001.218.1130","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T19:56:05Z","timestamp":1152302165000},"page":"1130-1135","source":"Crossref","is-referenced-by-count":59,"title":["Effect of hydroxyethyl starch infusion on colloid oncotic pressure in hypoproteinemic horses"],"prefix":"10.2460","volume":"218","author":[{"given":"Peyton A.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fairfield T.","family":"Bain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Douglas","family":"Byars","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Barry","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond C.","family":"Boston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1_200","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1113\/jphysiol.1896.sp000596","volume":"19","author":"Starling EH","year":"1896","journal-title":"J Physiol (London)"},{"key":"p_2_201","first-page":"961","author":"Landis EM","year":"1963","journal-title":"DC: American Physiological Society"},{"key":"p_3_202","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199855050-00002"},{"key":"p_4_203","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0268-960X(05)80021-9","volume":"7","author":"Salmon JB","year":"1993","journal-title":"Blood Rev"},{"key":"p_5_204","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0749-0704(18)30252-5","volume":"8","author":"Kaminski MV","year":"1992","journal-title":"Crit Care Clin"},{"key":"p_6_205","first-page":"127","volume":"1","author":"Astiz ME","year":"1993","journal-title":"New Horiz"},{"key":"p_7_206","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1097\/00007611-198905000-00019","volume":"82","author":"Haynes GR","year":"1989","journal-title":"South Med J"},{"key":"p_8_207","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0749-0704(18)30259-8","volume":"8","author":"Weinstein PD","year":"1992","journal-title":"Crit Care Clin"},{"key":"p_9_208","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1553-2712.1994.tb02559.x","volume":"1","author":"Rady M","year":"1994","journal-title":"Acad Emerg Med"},{"key":"p_10_209","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/00003246-198107000-00001","volume":"9","author":"Harms BA","year":"1981","journal-title":"Crit Care Med"},{"key":"p_11_210","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0039-6060(05)80211-9","volume":"117","author":"Myers GA","year":"1995","journal-title":"Surgery"},{"key":"p_12_211","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1152\/jappl.1987.62.6.2421","volume":"62","author":"Rackow EC","year":"1987","journal-title":"J Appl Physiol"},{"key":"p_13_212","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1152\/jappl.1994.77.3.1507","volume":"77","author":"Morisaki H","year":"1994","journal-title":"J Appl Physiol"},{"key":"p_14_213","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00000658-198601000-00005","volume":"203","author":"Nielsen OM","year":"1986","journal-title":"Ann Surg"},{"key":"p_15_214","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/00000658-198909000-00015","volume":"210","author":"Bock JC","year":"1989","journal-title":"Ann Surg"},{"key":"p_16_215","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/00003246-198311000-00001","volume":"11","author":"Rackow EC","year":"1983","journal-title":"Crit Care Med"},{"key":"p_17_216","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-9441(97)90001-0"},{"key":"p_18_217","first-page":"1751","volume":"47","author":"Allen","year":"1986","journal-title":"Am J Vet Res"},{"key":"p_19_218","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00003246-198203000-00004","volume":"10","author":"Haupt MT","year":"1982","journal-title":"Crit Care Med"},{"key":"p_20_219","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00003246-198902000-00005","volume":"17","author":"Hankeln K","year":"1989","journal-title":"Crit Care Med"},{"key":"p_21_220","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0308-2261(18)30034-1","volume":"13","author":"Mishler JM","year":"1984","journal-title":"Clin Haematol"},{"key":"p_22_221","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199608000-00001"},{"key":"p_23_222","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.50.1.337"},{"key":"p_24_223","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050833"},{"key":"p_25_224","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199701000-00037"},{"key":"p_26_225","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199608000-00010"},{"key":"p_27_226","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/00003246-198005000-00007","volume":"8","author":"Lazrove S","year":"1980","journal-title":"Crit Care Med"},{"key":"p_28_227","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2460\/ajvr.1997.58.05.541","volume":"58","author":"Jones PA","year":"1997","journal-title":"Am J Vet Res"},{"key":"p_29_228","doi-asserted-by":"publisher","DOI":"10.1007\/BF00254796"},{"key":"p_30_229","first-page":"807","volume":"68","author":"Nguyen HN","year":"1986","journal-title":"Obstet Gynecol"},{"key":"p_31_230","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/00003246-198011000-00003","volume":"8","author":"Sprung CL","year":"1980","journal-title":"Crit Care Med"},{"key":"p_32_231","first-page":"417","volume":"36","author":"Bartels C","year":"1995","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"p_33_232","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.2460\/ajvr.1992.53.12.2241","volume":"53","author":"Thomas LA","year":"1992","journal-title":"Am J Vet Res"},{"key":"p_34_233","doi-asserted-by":"crossref","first-page":"910","DOI":"10.2460\/ajvr.1994.55.07.910","volume":"55","author":"Brown SA","year":"1994","journal-title":"Am J Vet Res"},{"key":"p_35_234","first-page":"32","volume":"44","author":"Lumsden JH","year":"1980","journal-title":"Can J Comp Med"},{"key":"p_36_235","unstructured":"Green WH. Econometric analysis. 4th ed. Upper Saddle River, NJ: Prentice Hall Inc, 2000;469."},{"key":"p_37_236","unstructured":"Diggle PJ, Liang KY, Zeger SL. Analysis of longitudinal data. Oxford, England: Clarendon Press, 1996;117."},{"key":"p_38_237","unstructured":"Lindsey JK. Models for repeated measurements. Oxford, England: Clarendon Press, 1997;209."},{"key":"p_39_238","unstructured":"Stata reference manual: release 6. College Station, Tex: Stata Press, 1999;225-232, 360-369."},{"key":"p_40_239","unstructured":"Stata Technical Bulletin. College Station, Tex: Stata Press, 1998;43:35-39."},{"key":"p_41_240","first-page":"218","author":"Glantz SA","year":"1992","journal-title":"New York: McGraw-Hill Book Co"},{"key":"p_42_241","first-page":"199","volume":"36","author":"Yacobi A","year":"1982","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"p_43_242","first-page":"329","volume":"134","author":"Meister D","year":"1992","journal-title":"Schweiz Arch Tierheilkd"},{"key":"p_44_243","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1939-1676.1996.tb02066.x","volume":"10","author":"Moore LE","year":"1996","journal-title":"J Vet Intern Med"},{"key":"p_45_244","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/j.1552-4604.1982.tb02164.x","volume":"22","author":"Yacobi A","year":"1982","journal-title":"J Clin Pharmacol"},{"key":"p_46_245","first-page":"93","volume":"36","author":"Traber LD","year":"1992","journal-title":"Circ Shock"},{"key":"p_47_246","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00003246-199103000-00022","volume":"19","author":"Webb AR","year":"1991","journal-title":"Crit Care Med"},{"key":"p_48_247","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/00005373-199905000-00007","volume":"46","author":"Conhaim RL","year":"1999","journal-title":"J Trauma"},{"key":"p_49_248","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF02425053","volume":"20","author":"Collis RE","year":"1994","journal-title":"Intensive Care Med"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/218\/7\/javma.2001.218.1130.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/218\/7\/javma.2001.218.1130.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/218\/7\/javma.2001.218.1130.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T14:00:14Z","timestamp":1741356014000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/218\/7\/javma.2001.218.1130.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4,1]]},"references-count":49,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.2460\/javma.2001.218.1130","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2001,4,1]]}}}