{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T07:03:34Z","timestamp":1773471814007,"version":"3.50.1"},"reference-count":9,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2001,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To compare effects of an injectable\ndoramectin preparation with those of an injectable\nivermectin-clorsulon preparation on control of gastrointestinal\nnematodes and liver flukes and on\ngrowth performance in cattle.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Randomized complete block design.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201460 crossbred calves.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedures<\/jats:bold>\u2014Calves (20\/treatment group) were treated\nwith doramectin or ivermectin-clorsulon or were not\ntreated. Fecal samples were collected for nematode\nand <jats:italic>Fasciola hepatica<\/jats:italic> egg counts on day 0 and for up\nto 140 days after treatment. Cattle were weighed\nbefore treatment and at 28-day intervals until day 140.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014From day 7 through day 49, nematode egg\ncounts for calves treated with doramectin or with ivermectin-\nclorsulon were significantly lower than those\nfor untreated control calves. As the study progressed\nbeyond day 56, the percentages of cattle with fluke\neggs in their feces increased, but differences in regard\nto these percentages were not detected among the 3\ngroups. Average daily gain for the doramectin-treated\ncattle (0.79 kg\/d [1.74 lb\/d]) was significantly greater\nthan that for the cattle treated with ivermectin-clorsulon\n(0.71 kg\/d [1.56 lb\/d]); values for both groups were\nsignificantly greater than that for the control cattle\n(0.62 kg\/d [1.37 lb\/d]).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggest\nthat doramectin had a greater impact on subclinical\ngastrointestinal tract parasitism in calves, as\ndemonstrated by growth performance, than did ivermectin-\nclorsulon. In the Gulf Coast region of the\nUnited States, spring-born nursing beef calves may\nhave minimal grazing exposure to <jats:italic>F hepatica<\/jats:italic> during\nthe peak fluke transmission period; therefore, mature\nfluke burdens may be negligible at the beginning of\nthe fall season. (<jats:italic>J Am Vet Med Assoc<\/jats:italic> 2001;218:\n1465\u20131468)<\/jats:p>","DOI":"10.2460\/javma.2001.218.1465","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T18:39:00Z","timestamp":1138041540000},"page":"1465-1468","source":"Crossref","is-referenced-by-count":6,"title":["Effects of parenteral administration of doramectin or a combination of ivermectin and clorsulon on control of gastrointestinal nematode and liver fluke infections and on growth performance in cattle"],"prefix":"10.2460","volume":"218","author":[{"given":"Alvin F.","family":"Loyacano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry L.","family":"Skogerboe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andy A.","family":"DeRosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery A.","family":"Gurie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie K.","family":"Shostrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1_247","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0749-0720(15)31236-6","volume":"2","author":"Malone JB","year":"1986","journal-title":"Vet Clin North Am Food Anim Pract"},{"key":"p_2_248","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0749-0720(15)31232-9","volume":"2","author":"Gibbs HC","year":"1986","journal-title":"Vet Clin North Am Food Anim Pract"},{"key":"p_3_249","doi-asserted-by":"crossref","first-page":"126","DOI":"10.21423\/bovine-vol1982no17p126-133","volume":"17","author":"Malone JB","year":"1982","journal-title":"Bovine Pract"},{"key":"p_4_250","first-page":"687","volume":"5","author":"Kaplan RM","year":"1994","journal-title":"Compend Contin Educ Pract Vet"},{"key":"p_5_251","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(97)00074-5"},{"key":"p_6_252","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(97)00078-2"},{"key":"p_7_253","first-page":"706","volume":"141","author":"Cox DD","year":"1962","journal-title":"J Am Vet Med Assoc"},{"key":"p_8_254","doi-asserted-by":"crossref","first-page":"899","DOI":"10.2527\/1991.693899x","volume":"69","author":"Ansotegui RP","year":"1991","journal-title":"J Anim Sci"},{"key":"p_9_255","first-page":"9","author":"Loyacano AF","year":"1998","journal-title":"Louisiana Agricultural Experiment Station"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/218\/9\/javma.2001.218.1465.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/218\/9\/javma.2001.218.1465.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/218\/9\/javma.2001.218.1465.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:44:07Z","timestamp":1741355047000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/218\/9\/javma.2001.218.1465.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5,1]]},"references-count":9,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.2460\/javma.2001.218.1465","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2001,5,1]]}}}