{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:51:19Z","timestamp":1773287479717,"version":"3.50.1"},"reference-count":20,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2001,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine whether dogs in New York,\nNY are naturally infected with <jats:italic>Rickettsia akari<\/jats:italic>, the\ncausative agent of rickettsialpox in humans.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Serologic survey.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014311 dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Serum samples were obtained from\ndogs as a part of a study on Rocky Mountain spotted\nfever and borreliosis or when dogs were examined at\narea veterinary clinics for routine care. Dog owners\nwere asked to complete a questionnaire inquiring\nabout possible risk factors at the time serum samples\nwere obtained. Samples were tested for reactivity to\nspotted fever group rickettsiae by use of an enzyme\nimmunoassay (EIA). Twenty-two samples for which\nresults were positive were tested by use of an indirect\nimmunofluorescence antibody (IFA) assay followed\nby confirmatory cross-absorption testing.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Results of the EIA were positive for 24\n(7.7%) dogs. A history of tick infestation and increasing\nage were significantly associated with whether\ndogs were seropositive. Distribution of seropositive\ndogs was focal. Seventeen of the 22 samples submitted\nfor IFA testing had titers to <jats:italic>R rickettsii<\/jats:italic> and <jats:italic>R\nakari<\/jats:italic>; for 11 of these, titers to R akari were higher than\ntiters to <jats:italic>R rickettsii<\/jats:italic>. Cross-absorption testing indicated\nthat in 6 of 7 samples, infection was caused by <jats:italic>R\nakari<\/jats:italic>.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggest\nthat dogs can be naturally infected with <jats:italic>R akari<\/jats:italic>.\nFurther studies are needed to determine the incidence\nof <jats:italic>R akari<\/jats:italic> infection in dogs, whether infection\nis associated with clinical illness, and whether dogs\ncan serve as sentinels for human disease. (<jats:italic>J Am Vet\nMed Assoc<\/jats:italic> 2001;218:1780\u20131782)<\/jats:p>","DOI":"10.2460\/javma.2001.218.1780","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T18:34:15Z","timestamp":1138041255000},"page":"1780-1782","source":"Crossref","is-referenced-by-count":16,"title":["Serologic evidence of Rickettsia akari infection among dogs in a metropolitan city"],"prefix":"10.2460","volume":"218","author":[{"given":"James A.","family":"Comer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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