{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:08:59Z","timestamp":1785240539026,"version":"3.55.0"},"reference-count":47,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2001,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To conduct serologic surveillance for\n<jats:italic>Leishmania<\/jats:italic> spp in English Foxhounds from a kennel,\nas well as recipients of blood from these dogs, and\ndetermine whether <jats:italic>L infantum<\/jats:italic> organisms could be\ntransmitted via blood transfusion.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Serologic prevalence survey.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014120 English Foxhounds and 51 dogs of various\nbreeds receiving blood from these donors.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Foxhound blood donors, foxhound nondonors,\nand nonfoxhound blood recipient dogs were\nevaluated serologically for <jats:italic>Leishmania<\/jats:italic> spp by indirect\nfluorescent antibody testing. Dogs that received\npacked RBC (PRBC) transfusions from foxhound\ndonors from mid-1996 through mid-2000 were identified.\nFurthermore, dogs were serologically evaluated\nif they had received fresh frozen plasma (FFP) transfusions\nin 1999 and 2000 from seropositive foxhound\nblood donors.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Thirty percent of the English Foxhounds were\nseropositive for <jats:italic>Leishmania<\/jats:italic> spp (titer \u2265 1:16), although\nthe degree of seropositivity varied considerably during\nthe period. Furthermore, 57 foxhounds had been used\nas donors from 1996 to 2000, and 342 units of PRBC\nhad been transfused to at least 227 patients. All 25\ndogs screened that received PRBC from seronegative\nfoxhound donors tested negative, whereas 3 of 7 dogs\nthat received PRBC from seropositive donors tested\npositive. All 9 dogs that received FFP from seropositive\nfoxhound donors remained seronegative.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014To our knowledge,\nthis report documents the first transmission of\n<jats:italic>Leishmania<\/jats:italic> spp by blood transfusion. The use of foxhounds\nas blood donors may not be advisable in\nNorth America. 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