{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:05:10Z","timestamp":1790273110960,"version":"4.1.0"},"reference-count":19,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2001,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate the health and performance\nof young dairy calves vaccinated with a commercial\n<jats:italic>Mannheimia haemolytica<\/jats:italic> and <jats:italic>Pasteurella multocida<\/jats:italic>\nvaccine.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Randomized clinical trial.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014358 Holstein dairy calves between 14 and\n20 days of age on 8 farms.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Calves were randomly assigned to a\ncontrol or vaccinated group. The vaccine used was a\ncommercial modified-live <jats:italic>M haemolytica<\/jats:italic> and <jats:italic>P multocida<\/jats:italic>\nvaccine that was administered on days 0 and\n14. Calf weight was measured on day 0 and monthly\nfor 3 months. Farmers were asked to record any treatment\ngiven to the calves and the reason for treatment\nduring the 4 months of the study. Blood was collected\nfrom all calves on days 0 and 28, and titers of antibodies\nto <jats:italic>M haemolyticawere<\/jats:italic> determined by means\nof direct bacterial agglutination.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Mean daily gain was not significantly different\nbetween vaccinated and control calves. Vaccinated\ncalves had a significantly greater increase in antibody\ntiters (5.3-fold increase), compared with control calves\n(3.6-fold increase). There was no significant difference\nbetween vaccinated and control calves for any of the\ntreatment outcomes (number and duration of treatments\nand age at first and last treatments).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggest\nthat the <jats:italic>M haemolytica<\/jats:italic> and <jats:italic>P multocidavaccine<\/jats:italic>,\ngiven twice 2 weeks apart, was effective in increasing\ntiters of antibodies against <jats:italic>M haemolytica<\/jats:italic> in young\ndairy calves but did not improve calf performance or health. (<jats:italic>J Am Vet Med Assoc<\/jats:italic> 2001;219:1739\u20131742)<\/jats:p>","DOI":"10.2460\/javma.2001.219.1739","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T15:25:23Z","timestamp":1135178723000},"page":"1739-1742","source":"Crossref","is-referenced-by-count":21,"title":["Health and performance of young dairy calves vaccinated with a modified-live Mannheimia haemolytica and Pasteurella multocida vaccine"],"prefix":"10.2460","volume":"219","author":[{"given":"Pascale","family":"Aubry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorin D.","family":"Warnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuck L.","family":"Guard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce W.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"p_1_196","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5877(90)90008-6"},{"key":"p_2_197","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5877(90)90009-7"},{"key":"p_3_198","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5877(90)90006-4"},{"key":"p_4_199","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5877(90)90007-5"},{"key":"p_5_200","first-page":"1160","author":"Radostits OM","year":"2000","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_6_201","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.2460\/javma.1996.208.12.2035","volume":"208","author":"Virtala AK","year":"1996","journal-title":"J Am Vet Med Assoc"},{"key":"p_7_202","first-page":"66","volume":"189","author":"Baker JC","year":"1986","journal-title":"J Am Vet Med Assoc"},{"key":"p_8_203","doi-asserted-by":"crossref","first-page":"59","DOI":"10.21423\/bovine-vol1997no31.1p59-66","volume":"31","author":"Perino LJ","year":"1997","journal-title":"Bovine Pract"},{"key":"p_9_204","first-page":"23","volume":"18","author":"Stevens RD","year":"1997","journal-title":"Large Anim Pract"},{"key":"p_10_205","first-page":"818","volume":"137","author":"Reggiardo C","year":"1981","journal-title":"Adv Exp Med Biol"},{"key":"p_11_206","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5877(88)90015-3"},{"key":"p_12_207","first-page":"247","volume":"57","author":"Van Donkersgoed J","year":"1993","journal-title":"Can J Vet Res"},{"key":"p_13_208","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5877(86)90018-8"},{"key":"p_14_209","doi-asserted-by":"crossref","first-page":"18","DOI":"10.21423\/bovine-vol1998no32.1p18-21","volume":"32","author":"Loan RW","year":"1998","journal-title":"Bovine Pract"},{"key":"p_15_210","first-page":"178","volume":"62","author":"Mosier DA","year":"1998","journal-title":"Can J Vet Res"},{"key":"p_16_211","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(95)00187-5"},{"key":"p_17_212","first-page":"239","volume":"35","author":"Van Donkersgoed J","year":"1994","journal-title":"Can Vet J"},{"key":"p_18_213","first-page":"241","volume":"39","author":"Brar JS","year":"1978","journal-title":"Am J Vet Res"},{"key":"p_19_214","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(96)00055-7"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/219\/12\/javma.2001.219.1739.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/219\/12\/javma.2001.219.1739.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/219\/12\/javma.2001.219.1739.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T14:00:27Z","timestamp":1741356027000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/219\/12\/javma.2001.219.1739.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,15]]},"references-count":19,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.2460\/javma.2001.219.1739","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2001,12,15]]}}}