{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:10:12Z","timestamp":1759529412835,"version":"3.38.0"},"reference-count":35,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2001,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine tissue depletion of penicillin\nG in calves after oral ingestion with milk replacer\nand estimate a withdrawal period.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Longitudinal controlled trial.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201426 Holstein calves.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Once daily, 24 calves were fed milk\nreplacer containing procaine penicillin G (0.68 mg\/kg\n[0.31 mg\/lb] of body weight); 2 calves served as controls.\nAfter 1 feeding, 12 calves were euthanatized in\ngroups of 3 each 4, 6.5, 9.5, and 13 hours after feeding.\nAfter 14 days, 12 calves were euthanatized in\ngroups of 3 each 4, 6.5, 9.5, and 13 hours after the\nfinal feeding. Concentrations of penicillin G were\ndetermined in tissues, blood, and urine by use of\nhigh-performance liquid chromatography.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Penicillin G was not detected in muscle\nsamples of treated calves. The highest concentrations\nof penicillin G in plasma, kidney, and liver were 13\nng\/ml, 92 ng\/g, and 142 ng\/g, respectively. Thirteen\ncarcasses had violative drug residues; 12 had violative\nresidues in the liver only, and 1 had violative residues\nin the liver and kidney. A 21-hour withdrawal period\nwas estimated.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Liver had the\nhighest concentration of penicillin G and was most\nlikely to have violative residues. Feeding calves milk\ncontaining penicillin G has the potential to cause violative\ndrug residues in tissues. It is recommended to\nobserve an appropriate withdrawal time prior to\nslaughter if calves are fed milk from cows treated\nwith penicillin G. (<jats:italic>J Am Vet Med Assoc<\/jats:italic> 2001;219:\n346\u2013350)<\/jats:p>","DOI":"10.2460\/javma.2001.219.346","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T18:36:31Z","timestamp":1138041391000},"page":"346-350","source":"Crossref","is-referenced-by-count":3,"title":["Tissue disposition and depletion of penicillin G after oral administration with milk in unweaned dairy calves"],"prefix":"10.2460","volume":"219","author":[{"given":"Jeffrey M. 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