{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:41:55Z","timestamp":1769010115331,"version":"3.49.0"},"reference-count":21,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2001,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate the effect of ceftiofur for\ntreatment of postpartum cows with fever.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Multilocation randomized complete block\ndesign trial.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014330 cows.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Cows with rectal temperature \u2265 39.5 C\n(103.1 F) during the first 10 postpartum days were randomly\nassigned to a treatment (ceftiofur; 1 mg\/kg [0.45\nmg\/lb] of body weight daily for 3 days) or untreated\ncontrol group. Cure (no additional or alternative antimicrobial\ntreatment used, rectal temperature &lt; 39.5 C,\nand no other concurrent clinical signs of disease when\nevaluated at 9 or 10 days after enrollment), milk production,\nand rectal temperature were evaluated.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Ceftiofur-treated cows were significantly\nmore likely to be cured than control cows (56.0 vs\n28.9%, respectively), with an odds ratio of 3.14 when\nvaginal discharge (a factor with moderate interaction\nwith treatment) was present at enrollment. Among\ncows that had an abnormal calving (a significant interaction\nfactor), treated cows had first milking yield 2.27\nkg (5 lb) greater than control cows. Treated cows had a\nsignificantly greater reduction in rectal temperature\n(1.19 C [2.14 F]), compared with control cows (1.04 C\n[1.87 F]).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Parenteral\nadministration of ceftiofur significantly improved cure\nrate, milk yield, and rectal temperature in postpartum\ncows with fever and vaginal discharge or dystocia.\nThese findings provide information to determine\nappropriate treatment for postpartum cows, which for\nyears has been debated in the dairy industry. (<jats:italic>J Am\nVet Med Assoc<\/jats:italic> 2001;219:805\u2013808)<\/jats:p>","DOI":"10.2460\/javma.2001.219.805","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T20:09:55Z","timestamp":1152302995000},"page":"805-808","source":"Crossref","is-referenced-by-count":30,"title":["Multilocation trial of ceftiofur for treatment of postpartum cows with fever"],"prefix":"10.2460","volume":"219","author":[{"given":"Chun","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph F.","family":"Boucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth J.","family":"Dame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Modesto","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Nantel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sjoert","family":"Zuidhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Arfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogelio","family":"Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Neubauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1_344","first-page":"19","volume":"29","author":"Upham GL.","year":"1996","journal-title":"Bovine Proc"},{"key":"p_2_345","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.3168\/jds.S0022-0302(88)79846-X","volume":"71","author":"Stevenson JS","year":"1988","journal-title":"J Dairy Sci"},{"key":"p_3_346","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(86)90045-2"},{"key":"p_4_347","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5877(86)90026-7"},{"key":"p_5_348","first-page":"131","volume":"20","author":"Sandals WCD","year":"1979","journal-title":"Can Vet J"},{"key":"p_6_349","first-page":"1194","volume":"185","author":"Gustafsson BK","year":"1984","journal-title":"J Am Vet Med Assoc"},{"key":"p_7_350","doi-asserted-by":"crossref","first-page":"13","DOI":"10.21423\/bovine-vol1980no15p13-23","volume":"5","author":"Miller HV","year":"1980","journal-title":"Bovine Pract"},{"key":"p_8_351","first-page":"1404","author":"Arrioja-Dechert A","year":"1999","journal-title":"Mich: North American Compendiums Inc"},{"key":"p_9_352","unstructured":"SAS\/STAT user's guide: version 6. 4th ed. 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