{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:01:19Z","timestamp":1784674879784,"version":"3.55.0"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2002,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To compare clinical efficacy of pulse\nadministration with itraconazole versus once daily\nadministration for the treatment of cutaneous and\notic <jats:italic>M pachydermatis<\/jats:italic> infection in dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Randomized controlled trial.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201420 dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Dogs were treated with itraconazole orally\n(n = 10\/group), using a pulse administration regimen (5\nmg\/kg [2.3 mg\/lb], PO, q 24 h for 2 consecutive days per\nweek for 3 weeks) or once daily administration (5 mg\/kg,\nPO, q 24 h for 21 days). No other treatment was permitted.\nOn days 0 and 21, clinical severity of cutaneous\nand otic disease was assessed, and samples were collected\nfor cytologic examination and yeast culture.\nCytology (sum of the mean number of yeast organisms\nper oil immersion field for affected sites) and culture\n(mean of the score for extent of yeast growth for samples\nfrom affected sites) scores were calculated.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014For dogs in both treatment groups, clinical\nseverity of cutaneous and otic disease was significantly\ndecreased by day 21, but decrease in severity\nwas not significantly different between groups.\nSimilarly, skin cytology, skin culture, and ear culture\nscores were significantly decreased on day 21, compared\nwith day 0, for both groups, but decreases were\nnot significantly different between groups except that\ndogs in the pulse administration group had a significantly\ngreater decrease in ear culture scores than did\ndogs in the daily administration group. However, when\ncytology scores only for ear samples were analyzed,\nday 21 score was not significantly decreased, compared\nwith day 0 score, for either group.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggested\nthat both pulse administration and once daily\nadministration of itraconazole were efficacious in the\ntreatment of <jats:italic>M pachydermatis<\/jats:italic> cutaneous infection in\ndogs. However, adjunctive treatment may be needed\nin dogs with M pachydermatis otitis. (<jats:italic>J Am Vet Med\nAssoc<\/jats:italic> 2002;220:1807\u20131812)<\/jats:p>","DOI":"10.2460\/javma.2002.220.1807","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T18:38:06Z","timestamp":1138041486000},"page":"1807-1812","source":"Crossref","is-referenced-by-count":31,"title":["Comparison of pulse administration versus once daily administration of itraconazole for the treatment of Malassezia pachydermatis dermatitis and otitis in dogs"],"prefix":"10.2460","volume":"220","author":[{"given":"Lauren R.","family":"Pinchbeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hillier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Kowalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Kwochka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"p_1_63","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.2460\/javma.1996.208.07.1048","volume":"208","author":"Kennis RA","year":"1996","journal-title":"J Am Vet Med Assoc"},{"key":"p_2_64","first-page":"547","author":"Greene C","year":"1998","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_3_65","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2460\/javma.1992.201.06.879","volume":"201","author":"Plant JO","year":"1992","journal-title":"J Am Vet Med Assoc"},{"key":"p_4_66","first-page":"363","author":"Scott DW","year":"2001","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_5_67","first-page":"13","volume":"27","author":"Mason KV","year":"1991","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_6_68","first-page":"44","author":"Mason KV.","year":"1993","journal-title":"St Louis: Mosby Year Book Inc"},{"key":"p_7_69","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1748-5827.1995.tb02840.x","volume":"36","author":"Bond R","year":"1995","journal-title":"J Small Anim Pract"},{"key":"p_8_70","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0190-9622(08)81276-5","volume":"21","author":"Bickers DR","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"p_9_71","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/clinids\/9.Supplement_1.S15","volume":"9","author":"Van Cutsem J","year":"1987","journal-title":"Rev Infect Dis"},{"key":"p_10_72","first-page":"32","volume":"71","author":"Van Cutsem J","year":"1990","journal-title":"Br J Clin Pract"},{"key":"p_11_73","unstructured":"Cauwenbergh G, DeDoncker P. 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