{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:12:32Z","timestamp":1785265952552,"version":"3.55.0"},"reference-count":43,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine the effects of a commercially\navailable orally administered antacid agent containing\naluminum hydroxide and magnesium hydroxide\non abomasal luminal pH in clinically normal milkfed\ncalves.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Randomized trial.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20145 male dairy calves.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Throughout the study, calves were fed\nmilk replacer at 7:30 AM and 7:30 PM. Cannulae for pH\nelectrodes were placed in the abomasal body and\npyloric antrum. Treatments consisted of oral administration\nof a high (50 ml) or low (25 ml) dose of the\nantacid agent and oral administration of milk replacer\nalone (control). Antacid was given at 7:30 AM, 3:30 PM,\nand 11:30 PM, and luminal pH was monitored continuously\nfor 24 hours, beginning 15 minutes before\nadministration of the first dose of antacid.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Administration of the first dose of antacid\nat the time of the morning feeding resulted in an\nincrease in mean abomasal body luminal pH of &lt; 1 pH\nunit, whereas administration of the second and third\ndoses of the antacid caused transient (&lt; 3 hours)\nincreases in mean luminal pH of approximately 1.5\n(low dose) and 2.5 (high dose) pH units.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggest\nthat clinically normal milk-fed calves given a\ncommercially available antacid agent, PO, will have a\ntransient increase in abomasal luminal pH. Such\nagents may, therefore, have a role in the treatment of\nabomasal ulceration in calves; however, the long-term\neffects of orally administered antacid agents in milkfed\ncalves and the clinical efficacy of such agents in\ntreating abomasal ulceration remain to be determined.\n(<jats:italic>J Am Vet Med Assoc<\/jats:italic> 2002;220:74\u201379)<\/jats:p>","DOI":"10.2460\/javma.2002.220.74","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T18:38:00Z","timestamp":1138041480000},"page":"74-79","source":"Crossref","is-referenced-by-count":25,"title":["Effect of an orally administered antacid agent containing aluminum hydroxide and magnesium hydroxide on abomasal luminal pH in clinically normal milk-fed calves"],"prefix":"10.2460","volume":"220","author":[{"given":"Ahmed F.","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Constable","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil A.","family":"Misk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"p_1_208","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1136\/vr.125.5.109","volume":"125","author":"Breukink HJ","year":"1989","journal-title":"Vet Rec"},{"key":"p_2_209","first-page":"586","volume":"121","author":"Welchman D","year":"1987","journal-title":"Vet Rec"},{"key":"p_3_210","first-page":"303","volume":"64","author":"Aukema JJ","year":"1974","journal-title":"Cornell Vet"},{"key":"p_4_211","first-page":"354","volume":"18","author":"Hemmingsen I","year":"1966","journal-title":"Nord Vet Med"},{"key":"p_5_212","first-page":"202","volume":"15","author":"Jensen R","year":"1954","journal-title":"Am J Vet Res"},{"key":"p_6_213","first-page":"524","volume":"169","author":"Jensen R","year":"1976","journal-title":"J Am Vet Med Assoc"},{"key":"p_7_214","first-page":"213","volume":"73","author":"Smith DF","year":"1983","journal-title":"Cornell Vet"},{"key":"p_8_215","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/vr.129.13.279","volume":"129","author":"Braun U","year":"1991","journal-title":"Vet Rec"},{"key":"p_9_216","doi-asserted-by":"crossref","first-page":"127","DOI":"10.21423\/bovine-vol1994no28p127-135","volume":"28","author":"Dirksen GU.","year":"1994","journal-title":"Bovine Pract"},{"key":"p_10_217","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.1531"},{"key":"p_11_218","first-page":"282","volume":"94","author":"Navetat H","year":"1987","journal-title":"DTW Dtsch Tierarztl Wochenschr"},{"key":"p_12_219","first-page":"S91","volume":"4","author":"Rebhun WC","year":"1982","journal-title":"Compend Contin Educ Pract Vet"},{"key":"p_13_220","first-page":"448","volume":"183","author":"Palmer JE","year":"1983","journal-title":"J Am Vet Med Assoc"},{"key":"p_14_221","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1056\/NEJM197403072901007","volume":"290","author":"Morrissey JF","year":"1974","journal-title":"N Engl J Med"},{"key":"p_15_222","unstructured":"Dalton HR. 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