{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T02:46:25Z","timestamp":1782355585077,"version":"3.54.5"},"reference-count":43,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2002,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To establish a dosing regimen for potassium\nbromide and evaluate use of bromide to treat\nspontaneous seizures in cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Prospective and retrospective studies.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20147 healthy adult male cats and records of\n17 cats with seizures.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Seven healthy cats were administered\npotassium bromide (15 mg\/kg [6.8 mg\/lb], PO, q 12 h)\nuntil steady-state concentrations were reached.\nSerum samples for pharmacokinetic analysis were\nobtained weekly until bromide concentrations were\nnot detectable. Clinical data were obtained from\nrecords of 17 treated cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014In the prospective study, maximum serum\nbromide concentration was 1.1 \u00b1 0.2 mg\/mL at 8\nweeks. Mean disappearance half-life was 1.6 \u00b1 0.2\nweeks. Steady state was achieved at a mean of 5.3 \u00b1\n1.1 weeks. No adverse effects were detected and\nbromide was well tolerated. In the retrospective\nstudy, administration of bromide (n = 4) or bromide\nand phenobarbital (3) was associated with eradication\nof seizures in 7 of 15 cats (serum bromide concentration\nrange, 1.0 to 1.6 mg\/mL); however, bromide\nadministration was associated with adverse effects in\n8 of 16 cats. Coughing developed in 6 of these cats,\nleading to euthanasia in 1 cat and discontinuation of\nbromide administration in 2 cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Therapeutic\nconcentrations of bromide are attained within 2\nweeks in cats that receive 30 mg\/kg\/d (13.6 mg\/lb\/d)\norally. 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