{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:21:01Z","timestamp":1762100461867,"version":"3.38.0"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2002,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To compare effects of a commercially\navailable omeprazole paste and a compounded\nomeprazole suspension on healing of gastric ulcers in\nThoroughbred racehorses in active training.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Randomized controlled trial.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201432 horses with gastric ulcers.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Horses were assigned to 2 groups on the\nbasis of endoscopic gastric ulcer severity. Group-1\nhorses were treated with omeprazole suspension for\n30 days and with omeprazole paste for an additional\n30 days. Group-2 horses were treated with omeprazole\npaste for 30 days and omeprazole suspension for\nan additional 30 days. Serum omeprazole concentrations\nwere measured in 4 additional healthy horses\nafter administration of a single dose of each formulation.\nIn all instances, omeprazole was administered at\na dose of 4 mg\/kg (1.8 mg\/lb), PO.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Ulcer severity scores on day 0 were not\nsignificantly different between groups. On day 30,\nulcer severity score was significantly decreased,\ncompared with day-0 score, in group-2 but not in\ngroup-1 horses. On day 60, ulcer severity score was\nsignificantly decreased, compared with day-0 and\nday-30 scores, in group-1 horses. In group-2 horses,\nulcer severity score on day 60 was significantly lower\nthan the day-0 score but was not significantly different\nfrom the day-30 score. Maximum observed\nserum omeprazole concentration and area under the\nconcentration-time curve were significantly higher\nafter administration of the paste versus the suspension\nformulation.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggest\nthat although administration of the commercially\navailable paste omeprazole formulation was effective\nin promoting healing of gastric ulcers in these horses,\nadministration of the compounded omeprazole suspension\nwas ineffective. 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