{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:42:32Z","timestamp":1780465352822,"version":"3.54.1"},"reference-count":16,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2002,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine effectiveness of infusion of\n1 and 2% enilconazole for treatment of nasal and\nsinusal aspergillosis, respectively, in dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Case series.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201426 client-owned dogs with aspergillosis.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014All dogs had typical clinical signs of\naspergillosis and rhinoscopically visible intrasinusal or\nintranasal fungal plaques associated with turbinate\ndestruction. During rhinoscopy, affected nasal cavities\nand frontal sinuses were debrided meticulously.\nNineteen dogs (group A) were treated with 1% enilconazole\nby use of a modified noninvasive infusion\nprocedure. Seven dogs (group B) were treated with\n2% enilconazole via catheters that were placed via\nendoscopic guidance into the frontal sinuses. All dogs\nunderwent follow-up rhinoscopy for determination of\nfurther treatment until cure was established.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Age, disease duration, clinical score, and\nrhinoscopic score were similar for both groups before\ntreatment. In group A, 17 of 19 dogs were cured; 9,\n6, and 2 dogs were cured after 1, 2, or 3 treatments,\nrespectively. The remaining 2 dogs were euthanatized\nbefore the end of the treatment protocol. In\ngroup B, all dogs were cured; 6 dogs and 1 dog were\ncured after 1 or 2 treatments, respectively. Only\nminor adverse effects such as nasal discharge, epistaxis,\nand sneezing developed.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014After extensive\nrhinoscopic debridement, 1 and 2% enilconazole\ninfused into the nasal cavities and the frontal sinuses,\nrespectively, were effective for treatment of\naspergillosis in dogs. Intrasinusal administration via\nendoscopically placed catheters appeared to require\nfewer infusions for success. Follow-up rhinoscopy is\nstrongly advised. (<jats:italic>J Am Med Vet Assoc<\/jats:italic> 2002;221:1421\u20131425)<\/jats:p>","DOI":"10.2460\/javma.2002.221.1421","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T18:41:26Z","timestamp":1138041686000},"page":"1421-1425","source":"Crossref","is-referenced-by-count":50,"title":["Intranasal infusion of enilconazole for treatment of sinonasal aspergillosis in dogs"],"prefix":"10.2460","volume":"221","author":[{"given":"Jean-Luc","family":"Zonderland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph K.","family":"St\u00f6rk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy H.","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick J.","family":"Hamaide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc H.","family":"Balligand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile M.","family":"Clercx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"p_1","first-page":"41","volume":"13","author":"Sharp NJH","year":"1991","journal-title":"Compend Contin Educ Pract Vet"},{"key":"p_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/inpract.14.1.27","volume":"14","author":"Sharp NJH","year":"1992","journal-title":"In Pract"},{"key":"p_3","first-page":"404","author":"Sharp NJH","year":"1998","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1532-950X.1996.tb01419.x","volume":"25","author":"Mathews KG","year":"1996","journal-title":"Vet Surg"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2002.tb00434.x"},{"key":"p_6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2460\/javma.1998.212.01.67","volume":"212","author":"McCullough SM","year":"1998","journal-title":"J Am Vet Med Assoc"},{"key":"p_7","first-page":"48","volume":"184","author":"Harvey CE","year":"1984","journal-title":"J Am Vet Med Assoc"},{"key":"p_8","first-page":"782","volume":"194","author":"Sharp NJH","year":"1989","journal-title":"J Am Vet Med Assoc"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1991.tb00868.x"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1993.tb03167.x"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1995.tb01358.x"},{"key":"p_12","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2460\/javma.1998.213.04.501","volume":"213","author":"Mathews KG","year":"1998","journal-title":"J Am Vet Med Assoc"},{"key":"p_13","doi-asserted-by":"crossref","first-page":"264","DOI":"10.5326\/15473317-33-3-264","volume":"33","author":"Caulkett N","year":"1997","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1748-5827.1998.tb03638.x","volume":"39","author":"Bray JP","year":"1998","journal-title":"J Small Anim Pract"},{"key":"p_15","doi-asserted-by":"crossref","first-page":"487","DOI":"10.5326\/15473317-34-6-487","volume":"34","author":"Smith SA","year":"1998","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_16","first-page":"176","author":"McGinnis MR","year":"1991","journal-title":"Baltimore: The Williams & Wilkins Co"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/221\/10\/javma.2002.221.1421.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/221\/10\/javma.2002.221.1421.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/221\/10\/javma.2002.221.1421.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T14:00:11Z","timestamp":1741356011000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/221\/10\/javma.2002.221.1421.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,15]]},"references-count":16,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.2460\/javma.2002.221.1421","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2002,11,15]]}}}