{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T06:53:43Z","timestamp":1771916023058,"version":"3.50.1"},"reference-count":41,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2002,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To examine the relationship between\nexposure to <jats:italic>Neospora caninum<\/jats:italic> and abortion in dairy\ncows during their first, second, third, and fourth or\nlater lactations and to establish the main mode of\ntransmission in female calves from birth until their\nfirst pregnancy was terminated by abortion or parturition.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Prospective observational study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014460 Holstein cows and 79 female calves.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Cows were classified as seropositive or\nseronegative to <jats:italic>N caninum<\/jats:italic> within 7 days after calving;\nincidence of abortion was compared between\ngroups during different lactations. Blood samples\nwere collected from female calves before ingestion\nof colostrum and every 6 months until their first pregnancy\nwas terminated by abortion or parturition; number\nof seropositive calves was compared between\nseropositive and seronegative dams.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014During the first pregnancy of their second\nlactation, risk of abortion for seropositive cows was\n2.8 times that of seronegative cows. Among 10\ncalves born to seropositive cows, 4 were classified as\nseropositive at birth and thereafter. Among 69 calves\nborn to seronegative cows, all were classified as\nseronegative at birth; 67 calves remained seronegative\nthereafter.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Exposure to <jats:italic>N caninum<\/jats:italic> alone was not significantly associated with\nabortion in cows during the first, third, and fourth or\nlater lactations. Seropositive cows that have aborted\npreviously may have subsequent abortions attributable\nto <jats:italic>N caninum<\/jats:italic>. Congenital infection was the main\nmode of <jats:italic>N caninum<\/jats:italic> transmission in a cohort of female\ncalves. 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