{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T14:07:48Z","timestamp":1763388468978,"version":"3.38.0"},"reference-count":12,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2002,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine whether topical application of\na 10% fipronil solution would control signs of flea allergic\ndermatitis in cats housed under natural conditions.<\/jats:p>\n\t\t\t\t<jats:p><jats:bold>Design<\/jats:bold>\u2014Multicenter open clinical trial.<\/jats:p>\n\t\t\t\t<jats:p><jats:bold>Animals<\/jats:bold>\u201442 client-owned cats with flea allergic dermatitis.<\/jats:p>\n\t\t\t\t<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Study cats along with all other cats and\ndogs living in the same houses were treated with\n10% fipronil solution topically on days 0, 30, and 60.\nFlea counts and clinical assessments were performed\non study cats on days 0, 14, 30, 60, and 90.<\/jats:p>\n\t\t\t\t<jats:p><jats:bold>Results<\/jats:bold>\u2014Percentage reductions in geometric mean\nflea counts on days 14, 30, 60, and 90, compared with\nday-0 geometric mean count, were 75, 73, 85, and\n94%, respectively. Pruritus score was significantly\nimproved at each examination after day 0, and pruritus\nwas reduced or eliminated in 31 of 40 (78%) cats at\nthe final examination. Similarly, scores for severity of\nmiliary dermatitis and alopecia were significantly\nimproved at each examination, except for alopecia\nscore on day 14. Overall treatment efficacy, assessed\non day 90, was excellent for 28 (70%) cats, good for 6\n(15%), moderate for 3 (7.5%), and poor for 3 (7.5%).<\/jats:p>\n\t\t\t\t<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggest\nthat monthly topical application of fipronil is effective\nfor treatment of flea allergic dermatitis in cats\nhoused under natural conditions. (<jats:italic>J Am Vet Med Assoc<\/jats:italic>\n2002;221:254\u2013257)<\/jats:p>","DOI":"10.2460\/javma.2002.221.254","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T20:13:03Z","timestamp":1152303183000},"page":"254-257","source":"Crossref","is-referenced-by-count":14,"title":["Effect of topical application of fipronil in cats with flea allergic dermatitis"],"prefix":"10.2460","volume":"221","author":[{"given":"Linda","family":"Medleau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith A.","family":"Hnilica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Lower","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Alva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Clekis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Case","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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