{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:49:09Z","timestamp":1774460949943,"version":"3.50.1"},"reference-count":33,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2002,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine how rapidly trimethoprimsulfamethoxazole\naffects serum total thyroxine (T<jats:sub>4<\/jats:sub>)\nand thyroid-stimulating hormone (TSH) concentrations\nin euthyroid dogs and how quickly hormone\nconcentrations return to reference values following\ndiscontinuation of administration.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design<\/jats:bold>\u2014Prospective study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20147 healthy euthyroid dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Dogs were given trimethoprim-sulfamethoxazole\n(26.5 to 31.3 mg\/kg [12 to 14.2 mg\/lb],\nPO, q 12 h) for a maximum of 6 weeks. A CBC and\nSchirmer tear test were performed and serum total T<jats:sub>4<\/jats:sub>\nand TSH concentrations were measured weekly.\nAdministration of trimethoprim-sulfamethoxazole\nwas discontinued if total T<jats:sub>4<\/jats:sub> concentration was less\nthan the lower reference limit and TSH concentration\nwas greater than the upper reference limit or if persistent\nneutropenia developed.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Six dogs had total T<jats:sub>4<\/jats:sub> concentrations less\nthan the lower reference limit within 3 weeks; T<jats:sub>4<\/jats:sub>\nconcentration was decreased after 1 week in 3 of\nthese 6 dogs. In these 6 dogs, TSH concentration\nwas greater than the upper reference limit within 4\nweeks. In 1 dog, T<jats:sub>4<\/jats:sub> and TSH concentrations were\nnot affected, despite administration of trimethoprimsulfamethoxazole\nfor 6 weeks. Neutropenia developed\nin 4 dogs. In 1 dog, the neutropenia resolved\nwhile trimethoprim-sulfamethoxazole was still being\nadministered. In the other 3, neutrophil counts\nreturned to reference values 1 week after drug\nadministration was discontinued.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggest\nthat administration of trimethoprim-sulfamethoxazole\nat a dosage of 26.5 to 31.3 mg\/kg, PO, every 12\nhours can substantially alter serum total T<jats:sub>4<\/jats:sub> and TSH\nconcentrations and neutrophil counts in dogs within\nas short a time as a few weeks. 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